4KXC

Crystal structure of human aminopeptidase A complexed with glutamate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Glutamyl aminopeptidase	polymer	888	102719.5	1	UniProt (Q07075) Pfam (PF17900) Pfam (PF01433) Pfam (PF11838)	Homo sapiens (human)	EAP, Aminopeptidase A, AP-A, Differentiation antigen gp160
2	B, D, E (B, D, E)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		627.6	3	In PDB BIRD (PRD_900017) GlyTouCan (G47362BJ)		triacetyl-beta-chitotriose
3	C, F, G (C, F, G)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	3	In PDB GlyTouCan (G42666HT)
4	H (A)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
5	I, J (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
6	K (A)	GLUTAMIC ACID	non-polymer		147.1	1	Chemie (GLU)
7	L (A)	water	water		18.0	452	Chemie (HOH)

Sequence modifications

A: 76 - 957 (UniProt: Q07075)

PDB	External Database	Details
Arg 213	Gln 213	variant
Ala 218	Val 218	variant
His 958	-	expression tag
His 959	-	expression tag
His 960	-	expression tag
His 961	-	expression tag
His 962	-	expression tag
His 963	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	102719.5
Branched	Number of molecules	6
	Total formula weight	3156.0
Non-Polymers*	Number of molecules	4
	Total formula weight	655.0
All*	Total formula weight	106530.4

*Water molecules are not included.