4KTC
NS3/NS4A protease with inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Serine protease NS3 | polymer | 190 | 20024.9 | 2 | UniProt (P26662) Pfam (PF02907) | Hepatitis C virus (isolate Japanese) (HCV) | Hepacivirin, NS3P, p70 |
| 2 | B, D (B, D) | NS4A peptide | polymer | 16 | 1686.1 | 2 | Synthetic | ||
| 3 | E, G (A, C) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | F, H (A, C) | (2R,6S,13aR,14aR,16aS)-6-{[(cyclopentyloxy)carbonyl]amino}-14a-[(cyclopropylsulfonyl)carbamoyl]-5,16-dioxooctadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl 3,4-dihydroisoquinoline-2(1H)-carboxylate | non-polymer | 741.9 | 2 | BIRD (PRD_001133) Chemie (1X3) | |||
| 5 | I, J, K (A, C, D) | water | water | 18.0 | 39 | Chemie (HOH) |
Sequence modifications
A, C: 2 - 187 (UniProt: P26662)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Met 0 | - | expression tag |
| Ala 1 | - | expression tag |
| Ile 114 | Val 1140 | variant |
| Val 132 | Ile 1158 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 43422.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1614.6 | |
| All* | Total formula weight | 45036.6 |
