4KTC
NS3/NS4A protease with inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006508 | biological_process | proteolysis |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0019087 | biological_process | transformation of host cell by virus |
| C | 0006508 | biological_process | proteolysis |
| C | 0008236 | molecular_function | serine-type peptidase activity |
| C | 0019087 | biological_process | transformation of host cell by virus |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN A 201 |
| Chain | Residue |
| A | CYS97 |
| A | THR98 |
| A | CYS99 |
| A | CYS145 |
| A | SER147 |
| A | HOH310 |
| site_id | AC2 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE 1X3 A 202 |
| Chain | Residue |
| A | GLY58 |
| A | ASP79 |
| A | ASP81 |
| A | VAL132 |
| A | LEU135 |
| A | LYS136 |
| A | GLY137 |
| A | SER138 |
| A | SER139 |
| A | PHE154 |
| A | ARG155 |
| A | ALA156 |
| A | ALA157 |
| A | ASP168 |
| C | ASN49 |
| C | VAL51 |
| C | MET74 |
| C | TYR75 |
| C | MET179 |
| A | GLN41 |
| A | PHE43 |
| A | HIS57 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN C 201 |
| Chain | Residue |
| C | CYS97 |
| C | CYS99 |
| C | CYS145 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE 1X3 C 202 |
| Chain | Residue |
| C | PHE43 |
| C | HIS57 |
| C | GLY58 |
| C | ASP79 |
| C | ASP81 |
| C | ARG119 |
| C | VAL132 |
| C | LEU135 |
| C | LYS136 |
| C | GLY137 |
| C | SER138 |
| C | SER139 |
| C | PHE154 |
| C | ARG155 |
| C | ALA156 |
| C | ALA157 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU01166, ECO:0000305|PubMed:8389908, ECO:0000305|PubMed:8392606, ECO:0000305|PubMed:9060645 |
| Chain | Residue | Details |
| A | HIS57 | |
| C | HIS57 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU01166, ECO:0000305|PubMed:8389908, ECO:0000305|PubMed:8392606 |
| Chain | Residue | Details |
| A | ASP81 | |
| C | ASP81 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | ACT_SITE: Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU01166 |
| Chain | Residue | Details |
| A | SER139 | |
| C | SER139 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01166, ECO:0000269|PubMed:9060645 |
| Chain | Residue | Details |
| A | CYS97 | |
| A | CYS99 | |
| A | CYS145 | |
| A | HIS149 | |
| C | CYS97 | |
| C | CYS99 | |
| C | CYS145 | |
| C | HIS149 |
