4KSQ
Crystal Structure of Human B-raf bound to a DFG-out Inhibitor 5B
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Serine/threonine-protein kinase B-raf | polymer | 284 | 32322.4 | 2 | UniProt (P15056) Pfam (PF07714) | Homo sapiens (human) | Proto-oncogene B-Raf, p94, v-Raf murine sarcoma viral oncogene homolog B1 |
| 2 | C, D (A, B) | N-{7-cyano-6-[4-fluoro-3-({[3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-1,3-benzothiazol-2-yl}cyclopropanecarboxamide | non-polymer | 555.5 | 2 | Chemie (1SW) |
Sequence modifications
A, B: 444 - 725 (UniProt: P15056)
| PDB | External Database | Details |
|---|---|---|
| Gly 442 | - | expression tag |
| Ser 443 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 64644.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1111.0 | |
| All* | Total formula weight | 65755.8 |
