4KSQ

Crystal Structure of Human B-raf bound to a DFG-out Inhibitor 5B

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE 1SW A 901

Chain	Residue
A	ALA480
A	CYS531
A	GLY533
A	HIS573
A	PHE582
A	ILE591
A	GLY592
A	ASP593
A	PHE594
A	LYS482
A	GLU500
A	LEU504
A	LEU513
A	ILE526
A	THR528
A	GLN529
A	TRP530

---

site_id	AC2
Number of Residues	19
Details	BINDING SITE FOR RESIDUE 1SW B 901

Chain	Residue
B	ALA480
B	LYS482
B	GLU500
B	LEU504
B	ILE512
B	LEU513
B	ILE526
B	THR528
B	GLN529
B	TRP530
B	CYS531
B	GLY533
B	LEU566
B	HIS573
B	PHE582
B	ILE591
B	GLY592
B	ASP593
B	PHE594

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	21
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGSGSFGTVYkGkwhgd.............VAVK

Chain	Residue	Details
A	ILE462-LYS482

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site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKsnNIFL

Chain	Residue	Details
A	ILE571-LEU583

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027

Chain	Residue	Details
A	ASP575
B	ASP575

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	ILE462
A	LYS482
B	ILE462
B	LYS482

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER445
B	SER445

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
A	SER446
B	SER446

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Omega-N-methylarginine; by PRMT5 => ECO:0000269|PubMed:21917714

Chain	Residue	Details
A	ARG670
B	ARG670

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site_id	SWS_FT_FI6
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23907581

Chain	Residue	Details
A	LYS577
B	LYS577

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