4KP3

Crystal Structure of MyoVa-GTD in Complex with Two Cargos

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, B)	Unconventional myosin-Va	polymer	404	46106.3	2	UniProt (Q99104) Pfam (PF01843)	Mus musculus (mouse)	Dilute myosin heavy chain, non-muscle
2	B, E (C, D)	RILP-like protein 2	polymer	103	11608.0	2	UniProt (Q99LE1) Pfam (PF09744)	Mus musculus (mouse)	RILPL2, Rab-interacting lysosomal-like protein 2
3	C, F (E, F)	Melanophilin	polymer	43	4882.3	2	UniProt (Q91V27)	Mus musculus (mouse)	Exophilin-3, Leaden protein, Slp homolog lacking C2 domains a, SlaC2-a, Synaptotagmin-like protein 2a
4	G, H, I, J, K... (A, C, E, B, D...)	water	water		18.0	57	Chemie (HOH)

Sequence modifications

A, B: 1469 - 1853 (UniProt: Q99104)

PDB	External Database	Details
His 1450	-	expression tag
His 1451	-	expression tag
His 1452	-	expression tag
His 1453	-	expression tag
His 1454	-	expression tag
His 1455	-	expression tag
Ser 1456	-	expression tag
Ser 1457	-	expression tag
Gly 1458	-	expression tag
Leu 1459	-	expression tag
Gly 1460	-	expression tag
Val 1461	-	expression tag
Leu 1462	-	expression tag
Phe 1463	-	expression tag
Gln 1464	-	expression tag
Gly 1465	-	expression tag
Pro 1466	-	expression tag
Gly 1467	-	expression tag
Ser 1468	-	expression tag
Ser 1674	Cys 1674	engineered mutation

C, D: 1 - 97 (UniProt: Q99LE1)

PDB	External Database	Details
Gly -5	-	expression tag
Pro -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Glu -1	-	expression tag
Phe 0	-	expression tag

E, F: 170 - 208 (UniProt: Q91V27)

PDB	External Database	Details
Gly 166	-	expression tag
Pro 167	-	expression tag
Gly 168	-	expression tag
Ser 169	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	125193.1
All*	Total formula weight	125193.1

*Water molecules are not included.