4KKH
The crystal structure of inhibitor-bound JNK3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mitogen-activated protein kinase 10 | polymer | 365 | 42116.7 | 1 | UniProt (P53779) Pfam (PF00069) | Homo sapiens (human) | MAP kinase 10, MAPK 10, MAP kinase p49 3F12, Stress-activated protein kinase 1b, SAPK1b, Stress-activated protein kinase JNK3, c-Jun N-terminal kinase 3 |
| 2 | B (A) | cyclopropyl[(3R)-3-({4-[6-hydroxy-2-(naphthalen-2-yl)-1H-benzimidazol-1-yl]pyrimidin-2-yl}amino)piperidin-1-yl]methanone | non-polymer | 504.6 | 1 | Chemie (1RQ) | |||
| 3 | C (A) | water | water | 18.0 | 155 | Chemie (HOH) |
Sequence modifications
A: 40 - 402 (UniProt: P53779)
| PDB | External Database | Details |
|---|---|---|
| Met 38 | - | expression tag |
| Gly 39 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 42116.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 504.6 | |
| All* | Total formula weight | 42621.3 |
