4KKD
The X-ray crystal structure of Mannose-binding lectin-associated serine proteinase-3 reveals the structural basis for enzyme inactivity associated with the 3MC syndrome
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Mannan-binding lectin serine protease 1 | polymer | 433 | 48007.3 | 2 | UniProt (P48740) Pfam (PF00084) Pfam (PF00089) | Homo sapiens (human) | Complement factor MASP-3, Complement-activating component of Ra-reactive factor, Mannose-binding lectin-associated serine protease 1, MASP-1, Mannose-binding protein-associated serine protease, Ra-reactive factor serine protease p100, RaRF, Serine protease 5, Mannan-binding lectin serine protease 1 heavy chain, Mannan-binding lectin serine protease 1 light chain |
| 2 | C (B) | IMIDAZOLE | non-polymer | 69.1 | 1 | Chemie (IMD) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 201 | Chemie (HOH) |
Sequence modifications
A, B: 298 - 728 (UniProt: P48740)
| PDB | External Database | Details |
|---|---|---|
| Met 296 | - | expression tag |
| Ala 297 | - | expression tag |
| Gln 448 | Lys 448 | engineered mutation |
| Glu 666 | Gly 666 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 96014.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 69.1 | |
| All* | Total formula weight | 96083.7 |
