4KIN

Crystal structure of mitogen-activated protein kinase 14 (P38-H5) complex with 5-(2-CHLOROPHENYL)-N-(5-(CYCLOPROPYLCARBAMOYL)-2-METHYLPHENYL)-2-THIOPHENECARBOXAMIDE

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Mitogen-activated protein kinase 14	polymer	366	42105.0	4	UniProt (Q16539) Pfam (PF00069) In PDB	Homo sapiens (human)	MAP kinase 14, MAPK 14, Cytokine suppressive anti-inflammatory drug-binding protein, CSAID-binding protein, CSBP, MAP kinase MXI2, MAX-interacting protein 2, Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, Stress-activated protein kinase 2a, SAPK2a
2	A, B, C, D	5-(2-chlorophenyl)-N-[5-(cyclopropylcarbamoyl)-2-methylphenyl]thiophene-2-carboxamide	non-polymer		410.9	4	Chemie (1M8)
3		water	water		18.0	854	Chemie (HOH)

Sequence modifications

A, B, C, D: 2 - 360 (UniProt: Q16539)

PDB	External Database	Details
Met -5	-	expression tag
Ala -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	168420.0
Non-Polymers*	Number of molecules	4
	Total formula weight	1643.7
All*	Total formula weight	170063.7

*Water molecules are not included.