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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

4KIN

Crystal structure of mitogen-activated protein kinase 14 (P38-H5) complex with 5-(2-CHLOROPHENYL)-N-(5-(CYCLOPROPYLCARBAMOYL)-2-METHYLPHENYL)-2-THIOPHENECARBOXAMIDE

Functional Information from GO Data
ChainGOidnamespacecontents
A0000165biological_processMAPK cascade
A0000166molecular_functionnucleotide binding
A0000922cellular_componentspindle pole
A0001502biological_processcartilage condensation
A0001649biological_processosteoblast differentiation
A0002021biological_processresponse to dietary excess
A0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004707molecular_functionMAP kinase activity
A0004708molecular_functionMAP kinase kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0006351biological_processDNA-templated transcription
A0006357biological_processregulation of transcription by RNA polymerase II
A0006468biological_processprotein phosphorylation
A0006915biological_processapoptotic process
A0006935biological_processchemotaxis
A0007165biological_processsignal transduction
A0007166biological_processcell surface receptor signaling pathway
A0010628biological_processpositive regulation of gene expression
A0010831biological_processpositive regulation of myotube differentiation
A0016301molecular_functionkinase activity
A0016607cellular_componentnuclear speck
A0016740molecular_functiontransferase activity
A0019899molecular_functionenzyme binding
A0019903molecular_functionprotein phosphatase binding
A0030168biological_processplatelet activation
A0030316biological_processosteoclast differentiation
A0031098biological_processstress-activated protein kinase signaling cascade
A0031281biological_processpositive regulation of cyclase activity
A0032735biological_processpositive regulation of interleukin-12 production
A0032868biological_processresponse to insulin
A0033209biological_processtumor necrosis factor-mediated signaling pathway
A0034774cellular_componentsecretory granule lumen
A0035331biological_processnegative regulation of hippo signaling
A0035556biological_processintracellular signal transduction
A0035924biological_processcellular response to vascular endothelial growth factor stimulus
A0038066biological_processp38MAPK cascade
A0042770biological_processsignal transduction in response to DNA damage
A0043536biological_processpositive regulation of blood vessel endothelial cell migration
A0045648biological_processpositive regulation of erythrocyte differentiation
A0045663biological_processpositive regulation of myoblast differentiation
A0048010biological_processvascular endothelial growth factor receptor signaling pathway
A0048273molecular_functionmitogen-activated protein kinase p38 binding
A0051149biological_processpositive regulation of muscle cell differentiation
A0051403biological_processstress-activated MAPK cascade
A0051525molecular_functionNFAT protein binding
A0060348biological_processbone development
A0070935biological_process3'-UTR-mediated mRNA stabilization
A0071222biological_processcellular response to lipopolysaccharide
A0071223biological_processcellular response to lipoteichoic acid
A0071479biological_processcellular response to ionizing radiation
A0071493biological_processcellular response to UV-B
A0090090biological_processnegative regulation of canonical Wnt signaling pathway
A0090398biological_processcellular senescence
A0090400biological_processstress-induced premature senescence
A0098586biological_processcellular response to virus
A0098978cellular_componentglutamatergic synapse
A0099179biological_processregulation of synaptic membrane adhesion
A0106310molecular_functionprotein serine kinase activity
A1900015biological_processregulation of cytokine production involved in inflammatory response
A1901741biological_processpositive regulation of myoblast fusion
A1904813cellular_componentficolin-1-rich granule lumen
A2000379biological_processpositive regulation of reactive oxygen species metabolic process
B0000165biological_processMAPK cascade
B0000166molecular_functionnucleotide binding
B0000922cellular_componentspindle pole
B0001502biological_processcartilage condensation
B0001649biological_processosteoblast differentiation
B0002021biological_processresponse to dietary excess
B0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0004707molecular_functionMAP kinase activity
B0004708molecular_functionMAP kinase kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0006351biological_processDNA-templated transcription
B0006357biological_processregulation of transcription by RNA polymerase II
B0006468biological_processprotein phosphorylation
B0006915biological_processapoptotic process
B0006935biological_processchemotaxis
B0007165biological_processsignal transduction
B0007166biological_processcell surface receptor signaling pathway
B0010628biological_processpositive regulation of gene expression
B0010831biological_processpositive regulation of myotube differentiation
B0016301molecular_functionkinase activity
B0016607cellular_componentnuclear speck
B0016740molecular_functiontransferase activity
B0019899molecular_functionenzyme binding
B0019903molecular_functionprotein phosphatase binding
B0030168biological_processplatelet activation
B0030316biological_processosteoclast differentiation
B0031098biological_processstress-activated protein kinase signaling cascade
B0031281biological_processpositive regulation of cyclase activity
B0032735biological_processpositive regulation of interleukin-12 production
B0032868biological_processresponse to insulin
B0033209biological_processtumor necrosis factor-mediated signaling pathway
B0034774cellular_componentsecretory granule lumen
B0035331biological_processnegative regulation of hippo signaling
B0035556biological_processintracellular signal transduction
B0035924biological_processcellular response to vascular endothelial growth factor stimulus
B0038066biological_processp38MAPK cascade
B0042770biological_processsignal transduction in response to DNA damage
B0043536biological_processpositive regulation of blood vessel endothelial cell migration
B0045648biological_processpositive regulation of erythrocyte differentiation
B0045663biological_processpositive regulation of myoblast differentiation
B0048010biological_processvascular endothelial growth factor receptor signaling pathway
B0048273molecular_functionmitogen-activated protein kinase p38 binding
B0051149biological_processpositive regulation of muscle cell differentiation
B0051403biological_processstress-activated MAPK cascade
B0051525molecular_functionNFAT protein binding
B0060348biological_processbone development
B0070935biological_process3'-UTR-mediated mRNA stabilization
B0071222biological_processcellular response to lipopolysaccharide
B0071223biological_processcellular response to lipoteichoic acid
B0071479biological_processcellular response to ionizing radiation
B0071493biological_processcellular response to UV-B
B0090090biological_processnegative regulation of canonical Wnt signaling pathway
B0090398biological_processcellular senescence
B0090400biological_processstress-induced premature senescence
B0098586biological_processcellular response to virus
B0098978cellular_componentglutamatergic synapse
B0099179biological_processregulation of synaptic membrane adhesion
B0106310molecular_functionprotein serine kinase activity
B1900015biological_processregulation of cytokine production involved in inflammatory response
B1901741biological_processpositive regulation of myoblast fusion
B1904813cellular_componentficolin-1-rich granule lumen
B2000379biological_processpositive regulation of reactive oxygen species metabolic process
C0000165biological_processMAPK cascade
C0000166molecular_functionnucleotide binding
C0000922cellular_componentspindle pole
C0001502biological_processcartilage condensation
C0001649biological_processosteoblast differentiation
C0002021biological_processresponse to dietary excess
C0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
C0004672molecular_functionprotein kinase activity
C0004674molecular_functionprotein serine/threonine kinase activity
C0004707molecular_functionMAP kinase activity
C0004708molecular_functionMAP kinase kinase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005576cellular_componentextracellular region
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005829cellular_componentcytosol
C0006351biological_processDNA-templated transcription
C0006357biological_processregulation of transcription by RNA polymerase II
C0006468biological_processprotein phosphorylation
C0006915biological_processapoptotic process
C0006935biological_processchemotaxis
C0007165biological_processsignal transduction
C0007166biological_processcell surface receptor signaling pathway
C0010628biological_processpositive regulation of gene expression
C0010831biological_processpositive regulation of myotube differentiation
C0016301molecular_functionkinase activity
C0016607cellular_componentnuclear speck
C0016740molecular_functiontransferase activity
C0019899molecular_functionenzyme binding
C0019903molecular_functionprotein phosphatase binding
C0030168biological_processplatelet activation
C0030316biological_processosteoclast differentiation
C0031098biological_processstress-activated protein kinase signaling cascade
C0031281biological_processpositive regulation of cyclase activity
C0032735biological_processpositive regulation of interleukin-12 production
C0032868biological_processresponse to insulin
C0033209biological_processtumor necrosis factor-mediated signaling pathway
C0034774cellular_componentsecretory granule lumen
C0035331biological_processnegative regulation of hippo signaling
C0035556biological_processintracellular signal transduction
C0035924biological_processcellular response to vascular endothelial growth factor stimulus
C0038066biological_processp38MAPK cascade
C0042770biological_processsignal transduction in response to DNA damage
C0043536biological_processpositive regulation of blood vessel endothelial cell migration
C0045648biological_processpositive regulation of erythrocyte differentiation
C0045663biological_processpositive regulation of myoblast differentiation
C0048010biological_processvascular endothelial growth factor receptor signaling pathway
C0048273molecular_functionmitogen-activated protein kinase p38 binding
C0051149biological_processpositive regulation of muscle cell differentiation
C0051403biological_processstress-activated MAPK cascade
C0051525molecular_functionNFAT protein binding
C0060348biological_processbone development
C0070935biological_process3'-UTR-mediated mRNA stabilization
C0071222biological_processcellular response to lipopolysaccharide
C0071223biological_processcellular response to lipoteichoic acid
C0071479biological_processcellular response to ionizing radiation
C0071493biological_processcellular response to UV-B
C0090090biological_processnegative regulation of canonical Wnt signaling pathway
C0090398biological_processcellular senescence
C0090400biological_processstress-induced premature senescence
C0098586biological_processcellular response to virus
C0098978cellular_componentglutamatergic synapse
C0099179biological_processregulation of synaptic membrane adhesion
C0106310molecular_functionprotein serine kinase activity
C1900015biological_processregulation of cytokine production involved in inflammatory response
C1901741biological_processpositive regulation of myoblast fusion
C1904813cellular_componentficolin-1-rich granule lumen
C2000379biological_processpositive regulation of reactive oxygen species metabolic process
D0000165biological_processMAPK cascade
D0000166molecular_functionnucleotide binding
D0000922cellular_componentspindle pole
D0001502biological_processcartilage condensation
D0001649biological_processosteoblast differentiation
D0002021biological_processresponse to dietary excess
D0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
D0004672molecular_functionprotein kinase activity
D0004674molecular_functionprotein serine/threonine kinase activity
D0004707molecular_functionMAP kinase activity
D0004708molecular_functionMAP kinase kinase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005576cellular_componentextracellular region
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005829cellular_componentcytosol
D0006351biological_processDNA-templated transcription
D0006357biological_processregulation of transcription by RNA polymerase II
D0006468biological_processprotein phosphorylation
D0006915biological_processapoptotic process
D0006935biological_processchemotaxis
D0007165biological_processsignal transduction
D0007166biological_processcell surface receptor signaling pathway
D0010628biological_processpositive regulation of gene expression
D0010831biological_processpositive regulation of myotube differentiation
D0016301molecular_functionkinase activity
D0016607cellular_componentnuclear speck
D0016740molecular_functiontransferase activity
D0019899molecular_functionenzyme binding
D0019903molecular_functionprotein phosphatase binding
D0030168biological_processplatelet activation
D0030316biological_processosteoclast differentiation
D0031098biological_processstress-activated protein kinase signaling cascade
D0031281biological_processpositive regulation of cyclase activity
D0032735biological_processpositive regulation of interleukin-12 production
D0032868biological_processresponse to insulin
D0033209biological_processtumor necrosis factor-mediated signaling pathway
D0034774cellular_componentsecretory granule lumen
D0035331biological_processnegative regulation of hippo signaling
D0035556biological_processintracellular signal transduction
D0035924biological_processcellular response to vascular endothelial growth factor stimulus
D0038066biological_processp38MAPK cascade
D0042770biological_processsignal transduction in response to DNA damage
D0043536biological_processpositive regulation of blood vessel endothelial cell migration
D0045648biological_processpositive regulation of erythrocyte differentiation
D0045663biological_processpositive regulation of myoblast differentiation
D0048010biological_processvascular endothelial growth factor receptor signaling pathway
D0048273molecular_functionmitogen-activated protein kinase p38 binding
D0051149biological_processpositive regulation of muscle cell differentiation
D0051403biological_processstress-activated MAPK cascade
D0051525molecular_functionNFAT protein binding
D0060348biological_processbone development
D0070935biological_process3'-UTR-mediated mRNA stabilization
D0071222biological_processcellular response to lipopolysaccharide
D0071223biological_processcellular response to lipoteichoic acid
D0071479biological_processcellular response to ionizing radiation
D0071493biological_processcellular response to UV-B
D0090090biological_processnegative regulation of canonical Wnt signaling pathway
D0090398biological_processcellular senescence
D0090400biological_processstress-induced premature senescence
D0098586biological_processcellular response to virus
D0098978cellular_componentglutamatergic synapse
D0099179biological_processregulation of synaptic membrane adhesion
D0106310molecular_functionprotein serine kinase activity
D1900015biological_processregulation of cytokine production involved in inflammatory response
D1901741biological_processpositive regulation of myoblast fusion
D1904813cellular_componentficolin-1-rich granule lumen
D2000379biological_processpositive regulation of reactive oxygen species metabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues15
DetailsBINDING SITE FOR RESIDUE 1M8 A 401
ChainResidue
AVAL30
AALA111
AALA157
AASP168
APHE169
AHOH622
AHOH724
AALA51
ALYS53
AGLU71
ALEU75
AILE84
ALEU104
ATHR106
ALEU108
site_idAC2
Number of Residues17
DetailsBINDING SITE FOR RESIDUE 1M8 B 401
ChainResidue
BVAL30
BALA51
BLYS53
BGLU71
BLEU75
BILE84
BLEU104
BTHR106
BHIS107
BLEU108
BALA111
BALA157
BASP168
BPHE169
BLEU171
BHOH506
BHOH615
site_idAC3
Number of Residues15
DetailsBINDING SITE FOR RESIDUE 1M8 C 401
ChainResidue
CALA51
CLYS53
CGLU71
CLEU75
CILE84
CLEU104
CTHR106
CLEU108
CGLY110
CALA111
CLEU167
CASP168
CPHE169
CHOH585
CHOH596
site_idAC4
Number of Residues17
DetailsBINDING SITE FOR RESIDUE 1M8 D 401
ChainResidue
DTYR35
DVAL38
DALA51
DLYS53
DGLU71
DLEU75
DILE84
DLEU104
DTHR106
DLEU108
DGLY110
DALA111
DASP112
DLEU167
DASP168
DPHE169
DHOH524
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues25
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGSGAYGSVCaAfdtktglrv.........AVKK
ChainResidueDetails
AVAL30-LYS54
site_idPS01351
Number of Residues104
DetailsMAPK MAP kinase signature. FqsiihakrtyRElrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltddhvqfliyqilrglkyihsadiih.........RDlKpsnlavnedC
ChainResidueDetails
APHE59-CYS162
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsActive site: {"description":"Proton acceptor"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues20
DetailsBinding site: {}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues4
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues8
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"21444723","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine; by MAP2K3, MAP2K4, MAP2K6 and autocatalysis","evidences":[{"source":"PubMed","id":"7535770","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues4
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17525332","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues4
DetailsModified residue: {"description":"Phosphotyrosine; by ZAP70","evidences":[{"source":"PubMed","id":"15735648","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

246704

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