4KB6
Structure of porcine cyclic GMP AMP synthase (CGAS) in complex with DNA, ATP and GTP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Uncharacterized protein | polymer | 366 | 42470.2 | 1 | UniProt (I3LM39) Pfam (PF03281) Pfam (PF20266) | Sus scrofa (pigs swine wild boar) | |
| 2 | B, C (B, C) | DNA (5'-D(P*CP*GP*AP*CP*GP*CP*TP*AP*GP*CP*GP*TP*CP*G)-3') | polymer | 14 | 4281.8 | 2 | Synthetic DNA | ||
| 3 | D (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | E (A) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) | |||
| 5 | F (A) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (ATP) | |||
| 6 | G (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 7 | H (A) | water | water | 18.0 | 2 | Chemie (HOH) |
Sequence modifications
A: 135 - 497 (UniProt: I3LM39)
| PDB | External Database | Details |
|---|---|---|
| Gly 132 | - | expression tag |
| Ala 133 | - | expression tag |
| Met 134 | - | expression tag |
| Gln 200 | Glu 200 | engineered mutation |
| Asn 202 | Asp 202 | engineered mutation |
| Asp 268 | - | SEE REMARK 999 |
| Thr 269 | - | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 51033.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1120.1 | |
| All* | Total formula weight | 52153.8 |
