4KB6
Structure of porcine cyclic GMP AMP synthase (CGAS) in complex with DNA, ATP and GTP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Uncharacterized protein | polymer | 366 | 42470.2 | 1 | UniProt (I3LM39) Pfam (PF03281) Pfam (PF20266) In PDB | Sus scrofa (pigs swine wild boar) | |
| 2 | B, C | DNA (5'-D(P*CP*GP*AP*CP*GP*CP*TP*AP*GP*CP*GP*TP*CP*G)-3') | polymer | 14 | 4281.8 | 2 | Synthetic DNA | ||
| 3 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | A | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) | |||
| 5 | A | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (ATP) | |||
| 6 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 7 | water | water | 18.0 | 2 | Chemie (HOH) |
Sequence modifications
A: 135 - 497 (UniProt: I3LM39)
| PDB | External Database | Details |
|---|---|---|
| Gly 132 | - | expression tag |
| Ala 133 | - | expression tag |
| Met 134 | - | expression tag |
| Gln 200 | Glu 200 | engineered mutation |
| Asn 202 | Asp 202 | engineered mutation |
| Asp 268 | - | SEE REMARK 999 |
| Thr 269 | - | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 51033.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1120.1 | |
| All* | Total formula weight | 52153.8 |
