4K4W

Poliovirus polymerase elongation complex (r5+2_form)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, E)	RNA-directed RNA polymerase 3D-POL	polymer	471	53729.1	2	UniProt (P03300) Pfam (PF00680)	Human poliovirus 1	Genome polyprotein
2	B, F (B, F)	RNA (5'-R(P*GP*GP*GP*AP*GP*AP*UP*GP*AP*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*UP*CP*GP*UP*CP*GP*AP*AP*A)-3')	polymer	35	11260.7	2
3	C, E (C, G)	RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*AP*GP*AP*CP*C)-3')	polymer	18	5811.5	2
4	G, H, I, J, K... (A, B, C, E, G...)	water	water		18.0	109	Chemie (HOH)

Sequence modifications

A, E: 1 - 461 (UniProt: P03300)

PDB	External Database	Details
Ala 290	Cys 2038	engineered mutation
Asp 446	Leu 2194	engineered mutation
Gly 462	-	expression tag
Ser 463	-	expression tag
Ser 464	-	expression tag
Ser 465	-	expression tag
His 466	-	expression tag
His 467	-	expression tag
His 468	-	expression tag
His 469	-	expression tag
His 470	-	expression tag
His 471	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	141602.8
All*	Total formula weight	141602.8

*Water molecules are not included.