4K4I

Ternary crystal structures of a human DNA POLYMERASE LAMBDA IN COMPLEX WITH DNA AND (-)FTC-TP.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E, I, M (A, E, I, M)	DNA polymerase lambda	polymer	340	38254.6	4	UniProt (Q9UGP5) Pfam (PF14716) Pfam (PF10391) Pfam (PF14792) Pfam (PF14791)	Homo sapiens (human)	Pol Lambda, DNA polymerase beta-2, Pol beta2, DNA polymerase kappa
2	B, F, J, N (B, F, J, N)	DNA (5'-D(*CP*GP*GP*CP*GP*GP*TP*AP*CP*TP*G)-3')	polymer	11	3390.2	4
3	C, G, K, O (C, G, K, O)	DNA (5'-D(*CP*AP*GP*TP*AP*C)-3')	polymer	6	1793.2	4
4	D, H, L, P (D, H, L, P)	DNA (5'-D(P*GP*CP*CP*G)-3')	polymer	4	1191.8	4
5	AA, KA, Q, RA (E, I, A, M)	[[(2R,5S)-5-(4-azanyl-5-fluoranyl-2-oxidanylidene-pyrimidin-1-yl)-1,3-oxathiolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate	non-polymer		487.2	4	Chemie (1RY)
6	BA, CA, DA, EA, FA... (E, F, I, J, K...)	CALCIUM ION	non-polymer		40.1	23	Chemie (CA)
7	HA, JA, OA, X, XA... (E, F, I, A, M...)	ACETATE ION	non-polymer		59.0	6	Chemie (ACT)
8	GA, WA (E, M)	CACODYLATE ION	non-polymer		137.0	2	Chemie (CAC)
9	AB, BB, CB, DB, EB... (B, C, E, F, G...)	water	water		18.0	479	Chemie (HOH)

Sequence modifications

A, E, I, M: 245 - 575 (UniProt: Q9UGP5)

PDB	External Database	Details
Met 244	-	expression tag
Leu 576	-	expression tag
Glu 577	-	expression tag
His 578	-	expression tag
His 579	-	expression tag
His 580	-	expression tag
His 581	-	expression tag
His 582	-	expression tag
His 583	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	16
	Total formula weight	178519.3
Non-Polymers*	Number of molecules	35
	Total formula weight	3498.8
All*	Total formula weight	182018.1

*Water molecules are not included.