Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4K4I

Ternary crystal structures of a human DNA POLYMERASE LAMBDA IN COMPLEX WITH DNA AND (-)FTC-TP.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0006281	biological_process	DNA repair
A	0016779	molecular_function	nucleotidyltransferase activity
A	0034061	molecular_function	DNA polymerase activity
E	0003677	molecular_function	DNA binding
E	0003887	molecular_function	DNA-directed DNA polymerase activity
E	0006281	biological_process	DNA repair
E	0016779	molecular_function	nucleotidyltransferase activity
E	0034061	molecular_function	DNA polymerase activity
I	0003677	molecular_function	DNA binding
I	0003887	molecular_function	DNA-directed DNA polymerase activity
I	0006281	biological_process	DNA repair
I	0016779	molecular_function	nucleotidyltransferase activity
I	0034061	molecular_function	DNA polymerase activity
M	0003677	molecular_function	DNA binding
M	0003887	molecular_function	DNA-directed DNA polymerase activity
M	0006281	biological_process	DNA repair
M	0016779	molecular_function	nucleotidyltransferase activity
M	0034061	molecular_function	DNA polymerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	BINDING SITE FOR RESIDUE 1RY A 601

Chain	Residue
A	ARG386
A	PHE506
A	ALA510
A	ASN513
A	CA605
A	CA606
A	HOH702
A	HOH717
A	HOH720
A	HOH736
A	HOH773
A	GLY416
A	HOH786
B	DG5
C	DC6
A	SER417
A	ARG420
A	CYS425
A	GLY426
A	ASP427
A	ASP429
A	TYR505

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 602

Chain	Residue
A	SER339
A	ILE341
A	ALA344
A	HOH828
C	DA5
C	HOH103

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 603

Chain	Residue
A	CYS300
A	ILE302
A	ILE305
A	HOH822
D	DC3
M	LYS307

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 604

Chain	Residue
A	SER463
A	HOH757
A	HOH777
A	HOH796
A	HOH827
B	DT10

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 605

Chain	Residue
A	ASP427
A	ASP429
A	1RY601
A	HOH702

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 606

Chain	Residue
A	ASP427
A	ASP429
A	ASP490
A	1RY601
C	DC6

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA A 607

Chain	Residue
A	GLU396
A	GLN400
A	CYS412

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT A 608

Chain	Residue
A	LEU503
A	THR555
A	GLU556
A	HOH794
A	HOH799

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA B 101

Chain	Residue
B	HOH212
B	HOH213
B	HOH220

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT B 102

Chain	Residue
B	DG2
B	DG3
N	DC1

site_id	BC2
Number of Residues	21
Details	BINDING SITE FOR RESIDUE 1RY E 601

Chain	Residue
E	ARG386
E	GLY416
E	SER417
E	ARG420
E	CYS425
E	GLY426
E	ASP427
E	ASP429
E	TYR505
E	PHE506
E	ASN513
E	CA602
E	CA603
E	HOH733
E	HOH752
E	HOH753
E	HOH754
E	HOH761
E	HOH778
F	DG5
G	DC6

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA E 602

Chain	Residue
E	ASP427
E	ASP429
E	1RY601
E	HOH752

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA E 603

Chain	Residue
E	ASP427
E	ASP429
E	ASP490
E	1RY601

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA E 604

Chain	Residue
E	HOH754
E	HOH778

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 605

Chain	Residue
G	HOH101
E	SER339
E	ILE341
E	ALA344
E	HOH726
G	DA5

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA E 606

Chain	Residue
E	GLU396
E	GLN400
E	CYS412
E	HOH771

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CAC E 607

Chain	Residue
E	SER463
E	GLU465
E	HOH763
F	HOH209
I	ARG441

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT E 608

Chain	Residue
E	THR555
E	GLU556
E	HOH777

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA F 101

Chain	Residue
F	HOH203
F	HOH205
F	HOH206
F	HOH207

site_id	CC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACT F 102

Chain	Residue
F	DG2
F	DG3

site_id	CC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE 1RY I 601

Chain	Residue
I	ARG386
I	GLY416
I	SER417
I	ARG420
I	GLY426
I	ASP427
I	TYR505
I	SER509
I	ALA510
I	ASN513
I	ARG514
I	ARG517
I	CA604
I	HOH752
I	HOH763
I	HOH767
J	DG5
K	DC6

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA I 602

Chain	Residue
I	SER339
I	ILE341
I	ALA344
I	HOH714
K	DA5
K	HOH201

site_id	CC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA I 603

Chain	Residue
I	ASP427
I	ASP429
I	CA604
I	HOH751
I	HOH752
I	HOH756

site_id	CC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA I 604

Chain	Residue
I	ASP427
I	1RY601
I	CA603
I	HOH724
I	HOH752

site_id	CC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACT I 605

Chain	Residue
I	THR555
I	GLU556

site_id	CC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA J 101

Chain	Residue
J	DC4
J	DG6

site_id	CC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CA K 101

Chain	Residue
J	HOH202

site_id	DC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE 1RY M 601

Chain	Residue
M	ARG386
M	GLY416
M	SER417
M	ARG420
M	GLY426
M	TYR505
M	SER509
M	ALA510
M	ASN513
M	ARG517
M	CA605
M	HOH786
M	HOH801
M	HOH802
N	DG5
O	DC6

site_id	DC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA M 602

Chain	Residue
M	CYS300
M	ILE302
M	PRO303
M	ILE305
P	DC3

site_id	DC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA M 603

Chain	Residue
M	SER339
M	ILE341
M	ALA344
O	DA5
O	HOH101

site_id	DC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA M 604

Chain	Residue
M	ASP427
M	ASP429
M	CA605
M	HOH787

site_id	DC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA M 605

Chain	Residue
M	ASP427
M	ASP429
M	1RY601
M	CA604
M	HOH786

site_id	DC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CAC M 606

Chain	Residue
M	GLU318
M	HOH800
M	HOH812
M	HOH814

site_id	DC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ACT M 607

Chain	Residue
M	HIS290

site_id	DC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA N 101

Chain	Residue
M	HOH824
N	HOH208

Functional Information from PROSITE/UniProt

site_id	PS00522
Number of Residues	20
Details	DNA_POLYMERASE_X DNA polymerase family X signature. GSYrRGkatCgDVDVLIthP

Chain	Residue	Details
A	GLY416-PRO435

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	224
Details	Region: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"14992725","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	36
Details	Region: {"description":"Involved in primer binding","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"description":"Schiff-base intermediate with DNA","evidences":[{"source":"PubMed","id":"11457865","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17475573","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2PFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PFQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17475573","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2PFO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PFQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)