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4K4I

Ternary crystal structures of a human DNA POLYMERASE LAMBDA IN COMPLEX WITH DNA AND (-)FTC-TP.

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0003887molecular_functionDNA-directed DNA polymerase activity
A0006281biological_processDNA repair
A0016779molecular_functionnucleotidyltransferase activity
A0034061molecular_functionDNA polymerase activity
E0003677molecular_functionDNA binding
E0003887molecular_functionDNA-directed DNA polymerase activity
E0006281biological_processDNA repair
E0016779molecular_functionnucleotidyltransferase activity
E0034061molecular_functionDNA polymerase activity
I0003677molecular_functionDNA binding
I0003887molecular_functionDNA-directed DNA polymerase activity
I0006281biological_processDNA repair
I0016779molecular_functionnucleotidyltransferase activity
I0034061molecular_functionDNA polymerase activity
M0003677molecular_functionDNA binding
M0003887molecular_functionDNA-directed DNA polymerase activity
M0006281biological_processDNA repair
M0016779molecular_functionnucleotidyltransferase activity
M0034061molecular_functionDNA polymerase activity
Functional Information from PDB Data
site_idAC1
Number of Residues22
DetailsBINDING SITE FOR RESIDUE 1RY A 601
ChainResidue
AARG386
APHE506
AALA510
AASN513
ACA605
ACA606
AHOH702
AHOH717
AHOH720
AHOH736
AHOH773
AGLY416
AHOH786
BDG5
CDC6
ASER417
AARG420
ACYS425
AGLY426
AASP427
AASP429
ATYR505

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 602
ChainResidue
ASER339
AILE341
AALA344
AHOH828
CDA5
CHOH103

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 603
ChainResidue
ACYS300
AILE302
AILE305
AHOH822
DDC3
MLYS307

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 604
ChainResidue
ASER463
AHOH757
AHOH777
AHOH796
AHOH827
BDT10

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA A 605
ChainResidue
AASP427
AASP429
A1RY601
AHOH702

site_idAC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA A 606
ChainResidue
AASP427
AASP429
AASP490
A1RY601
CDC6

site_idAC7
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CA A 607
ChainResidue
AGLU396
AGLN400
ACYS412

site_idAC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ACT A 608
ChainResidue
ALEU503
ATHR555
AGLU556
AHOH794
AHOH799

site_idAC9
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CA B 101
ChainResidue
BHOH212
BHOH213
BHOH220

site_idBC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE ACT B 102
ChainResidue
BDG2
BDG3
NDC1

site_idBC2
Number of Residues21
DetailsBINDING SITE FOR RESIDUE 1RY E 601
ChainResidue
EARG386
EGLY416
ESER417
EARG420
ECYS425
EGLY426
EASP427
EASP429
ETYR505
EPHE506
EASN513
ECA602
ECA603
EHOH733
EHOH752
EHOH753
EHOH754
EHOH761
EHOH778
FDG5
GDC6

site_idBC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA E 602
ChainResidue
EASP427
EASP429
E1RY601
EHOH752

site_idBC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA E 603
ChainResidue
EASP427
EASP429
EASP490
E1RY601

site_idBC5
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CA E 604
ChainResidue
EHOH754
EHOH778

site_idBC6
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA E 605
ChainResidue
GHOH101
ESER339
EILE341
EALA344
EHOH726
GDA5

site_idBC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA E 606
ChainResidue
EGLU396
EGLN400
ECYS412
EHOH771

site_idBC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CAC E 607
ChainResidue
ESER463
EGLU465
EHOH763
FHOH209
IARG441

site_idBC9
Number of Residues3
DetailsBINDING SITE FOR RESIDUE ACT E 608
ChainResidue
ETHR555
EGLU556
EHOH777

site_idCC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA F 101
ChainResidue
FHOH203
FHOH205
FHOH206
FHOH207

site_idCC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE ACT F 102
ChainResidue
FDG2
FDG3

site_idCC3
Number of Residues18
DetailsBINDING SITE FOR RESIDUE 1RY I 601
ChainResidue
IARG386
IGLY416
ISER417
IARG420
IGLY426
IASP427
ITYR505
ISER509
IALA510
IASN513
IARG514
IARG517
ICA604
IHOH752
IHOH763
IHOH767
JDG5
KDC6

site_idCC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA I 602
ChainResidue
ISER339
IILE341
IALA344
IHOH714
KDA5
KHOH201

site_idCC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA I 603
ChainResidue
IASP427
IASP429
ICA604
IHOH751
IHOH752
IHOH756

site_idCC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA I 604
ChainResidue
IASP427
I1RY601
ICA603
IHOH724
IHOH752

site_idCC7
Number of Residues2
DetailsBINDING SITE FOR RESIDUE ACT I 605
ChainResidue
ITHR555
IGLU556

site_idCC8
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CA J 101
ChainResidue
JDC4
JDG6

site_idCC9
Number of Residues1
DetailsBINDING SITE FOR RESIDUE CA K 101
ChainResidue
JHOH202

site_idDC1
Number of Residues16
DetailsBINDING SITE FOR RESIDUE 1RY M 601
ChainResidue
MARG386
MGLY416
MSER417
MARG420
MGLY426
MTYR505
MSER509
MALA510
MASN513
MARG517
MCA605
MHOH786
MHOH801
MHOH802
NDG5
ODC6

site_idDC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA M 602
ChainResidue
MCYS300
MILE302
MPRO303
MILE305
PDC3

site_idDC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA M 603
ChainResidue
MSER339
MILE341
MALA344
ODA5
OHOH101

site_idDC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA M 604
ChainResidue
MASP427
MASP429
MCA605
MHOH787

site_idDC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA M 605
ChainResidue
MASP427
MASP429
M1RY601
MCA604
MHOH786

site_idDC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CAC M 606
ChainResidue
MGLU318
MHOH800
MHOH812
MHOH814

site_idDC7
Number of Residues1
DetailsBINDING SITE FOR RESIDUE ACT M 607
ChainResidue
MHIS290

site_idDC8
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CA N 101
ChainResidue
MHOH824
NHOH208

Functional Information from PROSITE/UniProt
site_idPS00522
Number of Residues20
DetailsDNA_POLYMERASE_X DNA polymerase family X signature. GSYrRGkatCgDVDVLIthP
ChainResidueDetails
AGLY416-PRO435

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Schiff-base intermediate with DNA => ECO:0000269|PubMed:11457865
ChainResidueDetails
ALYS312
ELYS312
ILYS312
MLYS312

site_idSWS_FT_FI2
Number of Residues16
DetailsBINDING: BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ
ChainResidueDetails
AARG386
ISER417
IGLY426
IASN513
MARG386
MSER417
MGLY426
MASN513
ASER417
AGLY426
AASN513
EARG386
ESER417
EGLY426
EASN513
IARG386

site_idSWS_FT_FI3
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ
ChainResidueDetails
AASP427
MASP427
MASP429
MASP490
AASP429
AASP490
EASP427
EASP429
EASP490
IASP427
IASP429
IASP490

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PDB entries from 2024-07-10

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