4K13
Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with dorzolamide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Carbonic anhydrase 2 | polymer | 257 | 28900.6 | 1 | UniProt (P00918) Pfam (PF00194) In PDB | Homo sapiens (human) | Carbonate dehydratase II, Carbonic anhydrase C, CAC, Carbonic anhydrase II, CA-II |
2 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
3 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 2 | Chemie (DMS) | |||
4 | A | (4S-TRANS)-4-(ETHYLAMINO)-5,6-DIHYDRO-6-METHYL-4H-THIENO(2,3-B)THIOPYRAN-2-SULFONAMIDE-7,7-DIOXIDE | non-polymer | 324.4 | 1 | Chemie (ETS) | |||
5 | water | water | 18.0 | 311 | Chemie (HOH) |
Sequence modifications
A: 4 - 261 (UniProt: P00918)
PDB | External Database | Details |
---|---|---|
Ser 65 | Ala 65 | engineered mutation |
Gln 67 | Asn 67 | engineered mutation |
Thr 69 | Glu 69 | engineered mutation |
Leu 131 | Phe 130 | engineered mutation |
Glu 170 | Lys 169 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 28900.6 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 546.1 | |
All* | Total formula weight | 29446.7 |