4K0V

Structural basis for angiopoietin-1 mediated signaling initiation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	TEK tyrosine kinase variant	polymer	529	58896.3	1	UniProt (Q59HG2) Pfam (PF10430) UniProt (by SIFTS) (Q02763) In PDB	Homo sapiens (human)
2	B	Angiopoietin-1	polymer	230	26313.7	1	UniProt (Q15389) Pfam (PF00147) In PDB	Homo sapiens (human)	ANG-1

Sequence modifications

A: 23 - 542 (UniProt: Q59HG2)

PDB	External Database	Details
Gly 543	-	expression tag
Ser 544	-	expression tag
Ala 545	-	expression tag
Ser 546	-	expression tag
Gly 547	-	expression tag
Leu 548	-	expression tag
Val 549	-	expression tag
Pro 550	-	expression tag
Arg 551	-	expression tag

B: 1 - 219 (UniProt: Q15389)

PDB	External Database	Details
Ala -4	-	expression tag
Glu -3	-	expression tag
Leu -2	-	expression tag
Ala -1	-	expression tag
Ser 0	-	expression tag
Gly 220	-	expression tag
Ser 221	-	expression tag
Leu 222	-	expression tag
Val 223	-	expression tag
Pro 224	-	expression tag
Arg 225	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	85210.0
All*	Total formula weight	85210.0

*Water molecules are not included.