4K0T
Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with chlorzolamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Carbonic anhydrase 2 | polymer | 257 | 28900.6 | 1 | UniProt (P00918) Pfam (PF00194) In PDB | Homo sapiens (human) | Carbonate dehydratase II, Carbonic anhydrase C, CAC, Carbonic anhydrase II, CA-II |
| 2 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 2 | Chemie (DMS) | |||
| 4 | A | 5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide | non-polymer | 275.7 | 1 | Chemie (D9Z) | |||
| 5 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | water | water | 18.0 | 239 | Chemie (HOH) |
Sequence modifications
A: 4 - 261 (UniProt: P00918)
| PDB | External Database | Details |
|---|---|---|
| Ser 65 | Ala 65 | engineered mutation |
| Gln 67 | Asn 67 | engineered mutation |
| Thr 69 | Glu 69 | engineered mutation |
| Leu 131 | Phe 130 | engineered mutation |
| Glu 170 | Lys 169 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 28900.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 589.5 | |
| All* | Total formula weight | 29490.1 |
