4JZJ

Crystal Structure of Receptor-Fab Complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (C, D)	Interleukin-3 receptor subunit alpha	polymer	287	33097.4	2	UniProt (P26951) Pfam (PF18611) Pfam (PF09240)	Homo sapiens (human)	IL-3 receptor subunit alpha, IL-3R subunit alpha, IL-3R-alpha, IL-3RA
2	C, E (A, H)	Fab Heavy Chain	polymer	221	23799.9	2		Mus musculus (mouse)
3	D, F (B, L)	Fab Light Chain	polymer	220	24256.7	2		Mus musculus (mouse)
4	G (E)	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-3)][beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1203.1	1	In PDB GlyTouCan (G23711JB)
5	H (F)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-3)][beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		878.8	1	In PDB GlyTouCan (G17345YW)
6	I (G)	alpha-L-fucopyranose-(1-3)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		513.5	1	In PDB GlyTouCan (G08300EX)
7	J, K (C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
8	L, M (D, H)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
9	N, O, P, Q, R... (C, D, A, B, H...)	water	water		18.0	39	Chemie (HOH)

Sequence modifications

C, D: 20 - 306 (UniProt: P26951)

PDB	External Database	Details
Lys 144	Asn 144	SEE REMARK 999
-	Arg 145	deletion
Val 298	Ala 299	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	162308.2
Branched	Number of molecules	3
	Total formula weight	2595.4
Non-Polymers*	Number of molecules	4
	Total formula weight	626.6
All*	Total formula weight	165530.2

*Water molecules are not included.