4JXH

Complexe of ARNO Sec7 domain with the protein-protein interaction inhibitor N-(4-hydroxy-2,6-dimethylphenyl)benzenesulfonamide at pH 8.5

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Cytohesin-2	polymer	217	24918.4	1	UniProt (Q99418) Pfam (PF01369)	Homo sapiens (human)	ARF exchange factor, ARF nucleotide-binding site opener, Protein ARNO, PH, SEC7 and coiled-coil domain-containing protein 2
2	B (A)	N-(4-hydroxy-2,6-dimethylphenyl)benzenesulfonamide	non-polymer		277.3	1	Chemie (HRC)
3	C (A)	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4)
4	D (A)	water	water		18.0	305	Chemie (HOH)

Sequence modifications

A: 56 - 251 (UniProt: Q99418)

PDB	External Database	Details
Met 35	-	expression tag
Gly 36	-	expression tag
Ser 37	-	expression tag
Ser 38	-	expression tag
His 39	-	expression tag
His 40	-	expression tag
His 41	-	expression tag
His 42	-	expression tag
His 43	-	expression tag
His 44	-	expression tag
Ser 45	-	expression tag
Ser 46	-	expression tag
Gly 47	-	expression tag
Leu 48	-	expression tag
Val 49	-	expression tag
Pro 50	-	expression tag
Arg 51	-	expression tag
Gly 52	-	expression tag
Ser 53	-	expression tag
His 54	-	expression tag
Met 55	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	24918.4
Non-Polymers*	Number of molecules	2
	Total formula weight	372.3
All*	Total formula weight	25290.7

*Water molecules are not included.