4JWR
Co-crystal structure of MDM2 with inhibitor {(2S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-[(2S)-1-hydroxybutan-2-yl]-3-oxomorpholin-2-yl}acetic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | E3 ubiquitin-protein ligase Mdm2 | polymer | 95 | 11099.0 | 3 | UniProt (Q00987) Pfam (PF02201) | Homo sapiens (human) | Double minute 2 protein, Hdm2, Oncoprotein Mdm2, p53-binding protein Mdm2 |
| 2 | D, E, F (A, B, C) | {(2S,5R,6S)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-[(2S)-1-hydroxybutan-2-yl]-3-oxomorpholin-2-yl}acetic acid | non-polymer | 452.3 | 3 | Chemie (1MY) PubChem (86730773) PubChem (89478318) PubChem (90341514) PubChem (90341783) PubChem (90371760) PubChem (71305074) PubChem (118622928) PubChem (118622830) PubChem (118631976) PubChem (118632061) PubChem (118633959) PubChem (122684496) PubChem (123427367) PubChem (154439209) PubChem (132128368) PubChem (132128507) PubChem (132128539) PubChem (132128540) PubChem (132128750) PubChem (144688118) PubChem (144688210) PubChem (163589549) PubChem (167175835) | |||
| 3 | G, H, I (A, B, C) | water | water | 18.0 | 67 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 33297.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1357.0 | |
| All* | Total formula weight | 34654.0 |
