4JT8
Crystal Structure of human SIRT3 with ELT inhibitor 28 [4-(4-{2-[(2,2-dimethylpropanoyl)amino]ethyl}piperidin-1-yl)thieno[3,2-d]pyrimidine-6-carboxamide[
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | polymer | 285 | 31612.3 | 1 | UniProt (Q9NTG7) Pfam (PF02146) In PDB | Homo sapiens (human) | hSIRT3, Regulatory protein SIR2 homolog 3, SIR2-like protein 3 |
2 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
3 | A | 4-(4-{2-[(2,2-dimethylpropanoyl)amino]ethyl}piperidin-1-yl)thieno[3,2-d]pyrimidine-6-carboxamide | non-polymer | 389.5 | 1 | Chemie (1NR) | |||
4 | water | water | 18.0 | 71 | Chemie (HOH) |
Sequence modifications
A: 118 - 399 (UniProt: Q9NTG7)
PDB | External Database | Details |
---|---|---|
Ser 115 | - | expression tag |
Asn 116 | - | expression tag |
Ala 117 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 31612.3 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 454.9 | |
All* | Total formula weight | 32067.3 |