4JT8

Crystal Structure of human SIRT3 with ELT inhibitor 28 [4-(4-{2-[(2,2-dimethylpropanoyl)amino]ethyl}piperidin-1-yl)thieno[3,2-d]pyrimidine-6-carboxamide[

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0017136	molecular_function	NAD-dependent histone deacetylase activity
A	0051287	molecular_function	NAD binding
A	0070403	molecular_function	NAD+ binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 401

Chain	Residue
A	CYS256
A	CYS259
A	CYS280
A	CYS283

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site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 1NR A 402

Chain	Residue
A	ASN229
A	ILE230
A	ASP231
A	HIS248
A	VAL292
A	PHE294
A	HOH502
A	HOH507
A	HOH552
A	ASP156
A	PHE157
A	TYR165
A	PHE180
A	GLN228

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00236, ECO:0000269|PubMed:12186850, ECO:0000269|PubMed:16788062, ECO:0000269|PubMed:18794531

Chain	Residue	Details
A	HIS248

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:23897466

Chain	Residue	Details
A	GLY145
A	GLN228
A	GLY319
A	ASN344

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site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:19535340, ECO:0000269|PubMed:23897466

Chain	Residue	Details
A	CYS256
A	CYS259
A	CYS280
A	CYS283

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q8R104

Chain	Residue	Details
A	LYS122

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