4JRA
CRYSTAL STRUCTURE OF THE BOTULINUM NEUROTOXIN A RECEPTOR-BINDING DOMAIN IN COMPLEX WITH THE LUMINAL DOMAIN Of SV2C
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Botulinum neurotoxin type A | polymer | 443 | 51724.6 | 2 | UniProt (P10845) Pfam (PF07953) Pfam (PF07951) UniProt (by SIFTS) (P0DPI1) | Clostridium botulinum | BoNT/A, Bontoxilysin-A, BOTOX, Botulinum neurotoxin A light chain, Botulinum neurotoxin A heavy chain |
| 2 | C, D (C, D) | Synaptic vesicle glycoprotein 2C | polymer | 136 | 15984.9 | 2 | UniProt (Q496J9) Pfam (PF13599) | Homo sapiens (human) | |
| 3 | E, F, G, H, I... (A) | CHLORIDE ION | non-polymer | 35.5 | 6 | Chemie (CL) | |||
| 4 | J, K (A) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 5 | M, N, O, P (A, B, C, D) | water | water | 18.0 | 82 | Chemie (HOH) |
Sequence modifications
A, B: 871 - 1296 (UniProt: P10845)
C, D: 456 - 574 (UniProt: Q496J9)
| PDB | External Database | Details |
|---|---|---|
| Met 854 | - | expression tag |
| Lys 855 | - | expression tag |
| Lys 856 | - | expression tag |
| His 857 | - | expression tag |
| His 858 | - | expression tag |
| His 859 | - | expression tag |
| His 860 | - | expression tag |
| His 861 | - | expression tag |
| His 862 | - | expression tag |
| Gly 863 | - | expression tag |
| Ser 864 | - | expression tag |
| Leu 865 | - | expression tag |
| Val 866 | - | expression tag |
| Pro 867 | - | expression tag |
| Arg 868 | - | expression tag |
| Gly 869 | - | expression tag |
| Ser 870 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 439 | - | expression tag |
| Lys 440 | - | expression tag |
| Lys 441 | - | expression tag |
| His 442 | - | expression tag |
| His 443 | - | expression tag |
| His 444 | - | expression tag |
| His 445 | - | expression tag |
| His 446 | - | expression tag |
| His 447 | - | expression tag |
| Gly 448 | - | expression tag |
| Ser 449 | - | expression tag |
| Leu 450 | - | expression tag |
| Val 451 | - | expression tag |
| Pro 452 | - | expression tag |
| Arg 453 | - | expression tag |
| Gly 454 | - | expression tag |
| Ser 455 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 135419.0 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 258.7 | |
| All* | Total formula weight | 135677.7 |
