4JRA

CRYSTAL STRUCTURE OF THE BOTULINUM NEUROTOXIN A RECEPTOR-BINDING DOMAIN IN COMPLEX WITH THE LUMINAL DOMAIN Of SV2C

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
B	0005576	cellular_component	extracellular region

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 1301

Chain	Residue
A	PHE1100

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site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 1302

Chain	Residue
A	ARG1034

---

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 1303

Chain	Residue
A	GLU1210

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 1304

Chain	Residue
A	LEU1097
A	LYS1098

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1305

Chain	Residue
A	SER1002
A	TYR1010
A	NA1306

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA A 1306

Chain	Residue
A	SER1008
A	CL1305
A	SER1002

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA A 1307

Chain	Residue
A	ASP1099
A	TYR1104
A	TYR1111

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1308

Chain	Residue
A	TYR980
A	GLN1003
A	MET1004

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Motif: {"description":"Host ganglioside-binding motif; interacts with GT1b","evidences":[{"source":"PubMed","id":"18704164","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27958736","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14731268","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"19650874","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2VU9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TPB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TPC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Region: {"description":"Interaction with host ganglioside GT1b","evidences":[{"source":"PubMed","id":"18704164","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27958736","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14731268","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2VU9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TPB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TPC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18704164","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27958736","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2VU9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TPB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TPC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18704164","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27958736","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14731268","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2VU9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TPB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TPC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	88
Details	Region: {"description":"(Microbial infection) C.botulinum neurotoxin type A-binding","evidences":[{"source":"PubMed","id":"27294781","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"27313224","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5JLV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"27313224","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28252640","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5JLV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27313224","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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