4JQG
Crystal structure of an inactive mutant of MMP-9 catalytic domain in complex with a fluorogenic synthetic peptidic substrate with a fluorine atom.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (P, Q) | fluorogenic peptidic substrate (8MC)PLG(PFF)(DNW)AR(NH2) | polymer | 9 | 1145.2 | 2 | |||
| 2 | B, D (A, B) | Matrix metalloproteinase-9 | polymer | 164 | 18280.3 | 2 | UniProt (P14780) Pfam (PF00413) | Homo sapiens (human) | MMP-9, 92 kDa gelatinase, 92 kDa type IV collagenase, Gelatinase B, GELB, 67 kDa matrix metalloproteinase-9, 82 kDa matrix metalloproteinase-9 |
| 3 | E, R (P, Q) | AZIDE ION | non-polymer | 42.0 | 2 | Chemie (AZI) | |||
| 4 | F, G, S, T (A, B) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 5 | H, J, U (A, B) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
| 6 | I, V, W (A, B) | STRONTIUM ION | non-polymer | 87.6 | 3 | Chemie (SR) | |||
| 7 | K, M, N, O, P... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 7 | Chemie (EDO) | |||
| 8 | L (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 9 | Q, X (A, B) | S-1,2-PROPANEDIOL | non-polymer | 76.1 | 2 | Chemie (PGO) | |||
| 10 | AA, BA, CA (B) | SODIUM ION | non-polymer | 23.0 | 3 | Chemie (NA) | |||
| 11 | DA, EA, FA, GA (P, A, Q, B) | water | water | 18.0 | 428 | Chemie (HOH) |
Sequence modifications
A, B: 107 - 216 (UniProt: P14780)
A, B: 217 - 269 (UniProt: P14780)
A, B: 217 - 269 (UniProt: P14780)
| PDB | External Database | Details |
|---|---|---|
| Ala 227 | Glu 402 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 38850.9 | |
| Non-Polymers* | Number of molecules | 25 |
| Total formula weight | 1476.5 | |
| All* | Total formula weight | 40327.4 |
