4JQG

Crystal structure of an inactive mutant of MMP-9 catalytic domain in complex with a fluorogenic synthetic peptidic substrate with a fluorine atom.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0031012	cellular_component	extracellular matrix
B	0004222	molecular_function	metalloendopeptidase activity
B	0006508	biological_process	proteolysis
B	0008237	molecular_function	metallopeptidase activity
B	0008270	molecular_function	zinc ion binding
B	0031012	cellular_component	extracellular matrix

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE AZI P 600

Chain	Residue
A	ALA189
A	HIS190
A	HIS226
A	ALA227
A	HIS230
A	ZN301
P	LEU3
P	GLY4
P	PFF5

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 301

Chain	Residue
A	HIS226
A	HIS230
A	HIS236
P	GLY4
P	AZI600

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 302

Chain	Residue
A	HIS175
A	ASP177
A	HIS190
A	HIS203

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 303

Chain	Residue
A	ASP182
A	GLY183
A	ASP185
A	LEU187
A	ASP205
A	GLU208

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SR A 304

Chain	Residue
A	ASP165
A	GLY197
A	GLN199
A	ASP201
A	HOH414
A	HOH562
A	HOH581

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 305

Chain	Residue
A	ASP131
A	ASP206
A	GLU208
A	PGO312
A	HOH577

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 306

Chain	Residue
A	LYS115
A	ARG265
A	LEU267
A	GLY269
B	PHE107

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 307

Chain	Residue
A	LEU114
A	GLY233
A	LEU234
A	ASP235
A	HOH425

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 308

Chain	Residue
A	LEU187
A	HIS190
A	HOH411
P	PRO2

---

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 309

Chain	Residue
A	ALA242
A	LEU243
A	ARG249
A	HOH446
A	HOH447
A	HOH557
P	PFF5

---

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 310

Chain	Residue
A	LYS115
A	TRP116
A	HIS117
A	HIS118
A	EDO311
A	HOH438
A	HOH589

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 311

Chain	Residue
A	GLY195
A	PRO196
A	EDO310
A	HOH448

---

site_id	BC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PGO A 312

Chain	Residue
A	ASP131
A	GLY197
A	ASP207
A	GLU208
A	LEU209
A	CA305
A	HOH450
A	HOH518
A	HOH576

---

site_id	BC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE AZI Q 600

Chain	Residue
B	ALA189
B	HIS190
B	HIS226
B	ALA227
B	HIS230
B	ZN301
Q	LEU3
Q	GLY4
Q	PFF5

---

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 301

Chain	Residue
B	HIS226
B	HIS230
B	HIS236
Q	GLY4
Q	AZI600

---

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 302

Chain	Residue
B	HIS175
B	ASP177
B	HIS190
B	HIS203

---

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 303

Chain	Residue
B	ASP205
B	GLU208
B	ASP182
B	GLY183
B	ASP185
B	LEU187

---

site_id	BC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SR B 304

Chain	Residue
B	ALA164
B	ASP165
B	GLY197
B	GLN199
B	ASP201
B	HOH448
B	HOH451

---

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SR B 305

Chain	Residue
B	ASP131
B	ASP206
B	GLU208
B	PGO306
B	HOH420

---

site_id	CC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PGO B 306

Chain	Residue
B	ASP131
B	LYS184
B	ASP206
B	ASP207
B	GLU208
B	LEU209
B	SR305
B	HOH500
B	HOH574

---

site_id	CC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO B 307

Chain	Residue
B	TYR179
B	HIS190
B	HOH491
Q	PRO2

---

site_id	CC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO B 308

Chain	Residue
B	HIS119

---

site_id	CC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA B 309

Chain	Residue
A	PRO255
A	HOH432
B	PRO255
B	HOH402
B	HOH464
B	HOH593

---

site_id	CC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA B 310

Chain	Residue
B	HOH433
B	HOH434
B	HOH435
B	HOH510
B	HOH584

---

site_id	CC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NA B 311

Chain	Residue
B	HIS117
B	HIS118

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PubMed","id":"12051944","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12051944","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12051944","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12077439","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---