4JQ1
AKR1C2 complex with naproxen
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Aldo-keto reductase family 1 member C2 | polymer | 331 | 37857.4 | 2 | UniProt (P52895) Pfam (PF00248) In PDB | Homo sapiens (human) | 3-alpha-HSD3, Chlordecone reductase homolog HAKRD, Dihydrodiol dehydrogenase 2, DD-2, DD2, Dihydrodiol dehydrogenase/bile acid-binding protein, DD/BABP, Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, Type III 3-alpha-hydroxysteroid dehydrogenase |
2 | A, B | (2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid | non-polymer | 230.3 | 2 | Chemie (NPS) | |||
3 | A, B | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 2 | Chemie (NAP) | |||
4 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
5 | A | L(+)-TARTARIC ACID | non-polymer | 150.1 | 1 | Chemie (TLA) | |||
6 | B | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
7 | water | water | 18.0 | 311 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 323 (UniProt: P52895)
PDB | External Database | Details |
---|---|---|
Leu 324 | - | expression tag |
Glu 325 | - | expression tag |
His 326 | - | expression tag |
His 327 | - | expression tag |
His 328 | - | expression tag |
His 329 | - | expression tag |
His 330 | - | expression tag |
His 331 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 75714.8 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 2316.5 | |
All* | Total formula weight | 78031.3 |