4JIB
Crystal structure of of PDE2-inhibitor complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | cGMP-dependent 3',5'-cyclic phosphodiesterase | polymer | 345 | 40225.1 | 4 | UniProt (O00408) Pfam (PF00233) | Homo sapiens (human) | Cyclic GMP-stimulated phosphodiesterase, CGS-PDE, cGSPDE |
| 2 | E, H, K, N (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | F, I, L, O (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 4 | G, J, M, P (A, B, C, D) | 1-(2-hydroxyethyl)-3-(2-methylbutan-2-yl)-5-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-6,7-dihydropyrazolo[4,3-e][1,4]diazepin-8(1H)-one | non-polymer | 420.5 | 4 | Chemie (1L6) | |||
| 5 | Q, R, S, T (A, B, C, D) | water | water | 18.0 | 1435 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 579 - 919 (UniProt: O00408)
| PDB | External Database | Details |
|---|---|---|
| Gly 575 | - | expression tag |
| Ser 576 | - | expression tag |
| Ala 577 | - | expression tag |
| Met 578 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 160900.4 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2040.9 | |
| All* | Total formula weight | 162941.3 |
