4JIB
Crystal structure of of PDE2-inhibitor complex
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
A | 0007165 | biological_process | signal transduction |
A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
B | 0007165 | biological_process | signal transduction |
B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
C | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
C | 0007165 | biological_process | signal transduction |
C | 0008081 | molecular_function | phosphoric diester hydrolase activity |
D | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
D | 0007165 | biological_process | signal transduction |
D | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE ZN A 1001 |
Chain | Residue |
A | HIS660 |
A | HIS696 |
A | ASP697 |
A | ASP808 |
A | HOH1120 |
A | HOH1454 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG A 1002 |
Chain | Residue |
A | HOH1445 |
A | HOH1454 |
A | HOH1465 |
A | ASP697 |
A | HOH1216 |
A | HOH1269 |
site_id | AC3 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE 1L6 A 1003 |
Chain | Residue |
A | TYR655 |
A | LEU809 |
A | ASP811 |
A | GLN812 |
A | TYR827 |
A | MET847 |
A | LEU858 |
A | GLN859 |
A | SER861 |
A | PHE862 |
A | HOH1102 |
A | HOH1110 |
A | HOH1360 |
D | HIS587 |
D | HOH1228 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE ZN B 1001 |
Chain | Residue |
B | HIS660 |
B | HIS696 |
B | ASP697 |
B | ASP808 |
B | HOH1103 |
B | HOH1456 |
site_id | AC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG B 1002 |
Chain | Residue |
B | ASP697 |
B | HOH1284 |
B | HOH1442 |
B | HOH1450 |
B | HOH1456 |
B | HOH1457 |
site_id | AC6 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE 1L6 B 1003 |
Chain | Residue |
B | TYR655 |
B | LEU809 |
B | GLN812 |
B | TYR827 |
B | MET847 |
B | LEU858 |
B | GLN859 |
B | SER861 |
B | PHE862 |
B | HOH1102 |
B | HOH1105 |
site_id | AC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE ZN C 1001 |
Chain | Residue |
C | HIS660 |
C | HIS696 |
C | ASP697 |
C | ASP808 |
C | HOH1107 |
C | HOH1425 |
site_id | AC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG C 1002 |
Chain | Residue |
C | ASP697 |
C | HOH1122 |
C | HOH1410 |
C | HOH1415 |
C | HOH1424 |
C | HOH1425 |
site_id | AC9 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE 1L6 C 1003 |
Chain | Residue |
B | GLN591 |
C | TYR655 |
C | LEU770 |
C | LEU809 |
C | ASP811 |
C | GLN812 |
C | ILE826 |
C | PHE830 |
C | MET847 |
C | PHE862 |
C | HOH1102 |
C | HOH1104 |
C | HOH1127 |
C | HOH1172 |
site_id | BC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE ZN D 1001 |
Chain | Residue |
D | HIS660 |
D | HIS696 |
D | ASP697 |
D | ASP808 |
D | HOH1120 |
D | HOH1176 |
site_id | BC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MG D 1002 |
Chain | Residue |
D | ASP697 |
D | HOH1176 |
D | HOH1429 |
D | HOH1436 |
D | HOH1446 |
D | HOH1459 |
site_id | BC3 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE 1L6 D 1003 |
Chain | Residue |
D | HOH1113 |
D | HOH1120 |
D | HOH1252 |
D | HOH1311 |
D | HOH1458 |
A | GLN591 |
D | TYR655 |
D | LEU770 |
D | ASP811 |
D | GLN812 |
D | ILE826 |
D | PHE830 |
D | MET847 |
D | SER861 |
D | PHE862 |
D | HOH1103 |
Functional Information from PROSITE/UniProt
site_id | PS00126 |
Number of Residues | 12 |
Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGtnNsF |
Chain | Residue | Details |
A | HIS696-PHE707 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Proton donor => ECO:0000250|UniProtKB:O76083 |
Chain | Residue | Details |
A | HIS656 | |
B | HIS656 | |
C | HIS656 | |
D | HIS656 |
site_id | SWS_FT_FI2 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15938621, ECO:0000269|PubMed:19828435, ECO:0000269|PubMed:23899287, ECO:0007744|PDB:1Z1L, ECO:0007744|PDB:3IBJ, ECO:0007744|PDB:3ITM, ECO:0007744|PDB:3ITU, ECO:0007744|PDB:4HTX, ECO:0007744|PDB:4HTZ, ECO:0007744|PDB:4JIB |
Chain | Residue | Details |
C | ASP808 | |
D | HIS660 | |
D | ASP697 | |
D | ASP808 | |
A | HIS660 | |
A | ASP697 | |
A | ASP808 | |
B | HIS660 | |
B | ASP697 | |
B | ASP808 | |
C | HIS660 | |
C | ASP697 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:15938621, ECO:0000269|PubMed:19828435, ECO:0000269|PubMed:23899287, ECO:0007744|PDB:1Z1L, ECO:0007744|PDB:3ITM, ECO:0007744|PDB:3ITU, ECO:0007744|PDB:4HTX, ECO:0007744|PDB:4HTZ, ECO:0007744|PDB:4JIB |
Chain | Residue | Details |
A | HIS696 | |
B | HIS696 | |
C | HIS696 | |
D | HIS696 |