4JIB
Crystal structure of of PDE2-inhibitor complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| A | 0007165 | biological_process | signal transduction |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| B | 0007165 | biological_process | signal transduction |
| B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| C | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| C | 0007165 | biological_process | signal transduction |
| C | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| D | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| D | 0007165 | biological_process | signal transduction |
| D | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN A 1001 |
| Chain | Residue |
| A | HIS660 |
| A | HIS696 |
| A | ASP697 |
| A | ASP808 |
| A | HOH1120 |
| A | HOH1454 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 1002 |
| Chain | Residue |
| A | HOH1445 |
| A | HOH1454 |
| A | HOH1465 |
| A | ASP697 |
| A | HOH1216 |
| A | HOH1269 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 1L6 A 1003 |
| Chain | Residue |
| A | TYR655 |
| A | LEU809 |
| A | ASP811 |
| A | GLN812 |
| A | TYR827 |
| A | MET847 |
| A | LEU858 |
| A | GLN859 |
| A | SER861 |
| A | PHE862 |
| A | HOH1102 |
| A | HOH1110 |
| A | HOH1360 |
| D | HIS587 |
| D | HOH1228 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN B 1001 |
| Chain | Residue |
| B | HIS660 |
| B | HIS696 |
| B | ASP697 |
| B | ASP808 |
| B | HOH1103 |
| B | HOH1456 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 1002 |
| Chain | Residue |
| B | ASP697 |
| B | HOH1284 |
| B | HOH1442 |
| B | HOH1450 |
| B | HOH1456 |
| B | HOH1457 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 1L6 B 1003 |
| Chain | Residue |
| B | TYR655 |
| B | LEU809 |
| B | GLN812 |
| B | TYR827 |
| B | MET847 |
| B | LEU858 |
| B | GLN859 |
| B | SER861 |
| B | PHE862 |
| B | HOH1102 |
| B | HOH1105 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN C 1001 |
| Chain | Residue |
| C | HIS660 |
| C | HIS696 |
| C | ASP697 |
| C | ASP808 |
| C | HOH1107 |
| C | HOH1425 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG C 1002 |
| Chain | Residue |
| C | ASP697 |
| C | HOH1122 |
| C | HOH1410 |
| C | HOH1415 |
| C | HOH1424 |
| C | HOH1425 |
| site_id | AC9 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE 1L6 C 1003 |
| Chain | Residue |
| B | GLN591 |
| C | TYR655 |
| C | LEU770 |
| C | LEU809 |
| C | ASP811 |
| C | GLN812 |
| C | ILE826 |
| C | PHE830 |
| C | MET847 |
| C | PHE862 |
| C | HOH1102 |
| C | HOH1104 |
| C | HOH1127 |
| C | HOH1172 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN D 1001 |
| Chain | Residue |
| D | HIS660 |
| D | HIS696 |
| D | ASP697 |
| D | ASP808 |
| D | HOH1120 |
| D | HOH1176 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG D 1002 |
| Chain | Residue |
| D | ASP697 |
| D | HOH1176 |
| D | HOH1429 |
| D | HOH1436 |
| D | HOH1446 |
| D | HOH1459 |
| site_id | BC3 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE 1L6 D 1003 |
| Chain | Residue |
| D | HOH1113 |
| D | HOH1120 |
| D | HOH1252 |
| D | HOH1311 |
| D | HOH1458 |
| A | GLN591 |
| D | TYR655 |
| D | LEU770 |
| D | ASP811 |
| D | GLN812 |
| D | ILE826 |
| D | PHE830 |
| D | MET847 |
| D | SER861 |
| D | PHE862 |
| D | HOH1103 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGtnNsF |
| Chain | Residue | Details |
| A | HIS696-PHE707 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"O76083","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15938621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19828435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23899287","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Z1L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ITM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ITU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HTX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JIB","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15938621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19828435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23899287","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Z1L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ITM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ITU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HTX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JIB","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
