4JHW

Crystal Structure of Respiratory Syncytial Virus Fusion Glycoprotein Stabilized in the Prefusion Conformation by Human Antibody D25

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (H)	D25 antigen-binding fragment heavy chain	polymer	230	24375.4	1		Homo sapiens
2	B (L)	D25 light chain	polymer	214	23325.9	1		Homo sapiens
3	C (F)	Fusion glycoprotein F0	polymer	498	55014.6	1	UniProt (P03420) Pfam (PF00523)	Human respiratory syncytial virus	Protein F, Fusion glycoprotein F2, Fusion glycoprotein F1

Sequence modifications

F: 26 - 136 (UniProt: P03420)

PDB	External Database	Details
Ala 129	Pro 102	engineered mutation

F: 137 - 513 (UniProt: P03420)

PDB	External Database	Details
Val 379	Ile 379	engineered mutation
Val 447	Met 447	engineered mutation
Ser 514	-	expression tag
Ala 515	-	expression tag
Ile 516	-	expression tag
Gly 517	-	expression tag
Gly 518	-	expression tag
Tyr 519	-	expression tag
Ile 520	-	expression tag
Pro 521	-	expression tag
Glu 522	-	expression tag
Ala 523	-	expression tag
Pro 524	-	expression tag
Arg 525	-	expression tag
Asp 526	-	expression tag
Gly 527	-	expression tag
Gln 528	-	expression tag
Ala 529	-	expression tag
Tyr 530	-	expression tag
Val 531	-	expression tag
Arg 532	-	expression tag
Lys 533	-	expression tag
Asp 534	-	expression tag
Gly 535	-	expression tag
Glu 536	-	expression tag
Trp 537	-	expression tag
Val 538	-	expression tag
Leu 539	-	expression tag
Leu 540	-	expression tag
Ser 541	-	expression tag
Thr 542	-	expression tag
Phe 543	-	expression tag
Leu 544	-	expression tag
Gly 545	-	expression tag
Gly 546	-	expression tag
Leu 547	-	expression tag
Val 548	-	expression tag
Pro 549	-	expression tag
Arg 550	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	102715.9
All*	Total formula weight	102715.9

*Water molecules are not included.