4JGH

Structure of the SOCS2-Elongin BC complex bound to an N-terminal fragment of Cullin5

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Suppressor of cytokine signaling 2	polymer	173	19812.8	1	UniProt (O14508) Pfam (PF00017) Pfam (PF07525) In PDB	Homo sapiens (human)	SOCS-2, Cytokine-inducible SH2 protein 2, CIS-2, STAT-induced STAT inhibitor 2, SSI-2
2	B	Transcription elongation factor B polypeptide 2	polymer	118	13185.8	1	UniProt (P62869) Pfam (PF00240) In PDB	Mus musculus (mouse)	Elongin 18 kDa subunit, Elongin-B, EloB, RNA polymerase II transcription factor SIII subunit B, SIII p18
3	C	Transcription elongation factor B polypeptide 1	polymer	96	10869.5	1	UniProt (P83940) Pfam (PF03931) In PDB	Mus musculus (mouse)	Elongin 15 kDa subunit, Elongin-C, EloC, RNA polymerase II transcription factor SIII subunit C, SIII p15, Stromal membrane-associated protein SMAP1B homolog
4	D	Cullin-5	polymer	378	44010.4	1	UniProt (Q93034) Pfam (PF00888) In PDB	Homo sapiens (human)	CUL-5, Vasopressin-activated calcium-mobilizing receptor 1, VACM-1

Sequence modifications

A: 32 - 198 (UniProt: O14508)

PDB	External Database	Details
His 26	-	expression tag
Met 27	-	expression tag
Asp 28	-	expression tag
Pro 29	-	expression tag
Glu 30	-	expression tag
Phe 31	-	expression tag

C: 17 - 112 (UniProt: P83940)

PDB	External Database	Details
Pro 100	Ala 100	SEE REMARK 999

D: 10 - 386 (UniProt: Q93034)

PDB	External Database	Details
Arg 341	Val 341	engineered mutation
Asp 345	Leu 345	engineered mutation
Val 387	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	87878.5
All*	Total formula weight	87878.5

*Water molecules are not included.