4JGH
Structure of the SOCS2-Elongin BC complex bound to an N-terminal fragment of Cullin5
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Suppressor of cytokine signaling 2 | polymer | 173 | 19812.8 | 1 | UniProt (O14508) Pfam (PF00017) Pfam (PF07525) In PDB | Homo sapiens (human) | SOCS-2, Cytokine-inducible SH2 protein 2, CIS-2, STAT-induced STAT inhibitor 2, SSI-2 |
2 | B | Transcription elongation factor B polypeptide 2 | polymer | 118 | 13185.8 | 1 | UniProt (P62869) Pfam (PF00240) In PDB | Mus musculus (mouse) | Elongin 18 kDa subunit, Elongin-B, EloB, RNA polymerase II transcription factor SIII subunit B, SIII p18 |
3 | C | Transcription elongation factor B polypeptide 1 | polymer | 96 | 10869.5 | 1 | UniProt (P83940) Pfam (PF03931) In PDB | Mus musculus (mouse) | Elongin 15 kDa subunit, Elongin-C, EloC, RNA polymerase II transcription factor SIII subunit C, SIII p15, Stromal membrane-associated protein SMAP1B homolog |
4 | D | Cullin-5 | polymer | 378 | 44010.4 | 1 | UniProt (Q93034) Pfam (PF00888) In PDB | Homo sapiens (human) | CUL-5, Vasopressin-activated calcium-mobilizing receptor 1, VACM-1 |
Sequence modifications
A: 32 - 198 (UniProt: O14508)
C: 17 - 112 (UniProt: P83940)
D: 10 - 386 (UniProt: Q93034)
PDB | External Database | Details |
---|---|---|
His 26 | - | expression tag |
Met 27 | - | expression tag |
Asp 28 | - | expression tag |
Pro 29 | - | expression tag |
Glu 30 | - | expression tag |
Phe 31 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Pro 100 | Ala 100 | SEE REMARK 999 |
PDB | External Database | Details |
---|---|---|
Arg 341 | Val 341 | engineered mutation |
Asp 345 | Leu 345 | engineered mutation |
Val 387 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 87878.5 | |
All* | Total formula weight | 87878.5 |