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4JGH

Structure of the SOCS2-Elongin BC complex bound to an N-terminal fragment of Cullin5

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1ASuppressor of cytokine signaling 2polymer17319812.81UniProt (O14508)
Pfam (PF00017)
Pfam (PF07525)
In PDB
Homo sapiens (human)SOCS-2, Cytokine-inducible SH2 protein 2, CIS-2, STAT-induced STAT inhibitor 2, SSI-2
2BTranscription elongation factor B polypeptide 2polymer11813185.81UniProt (P62869)
Pfam (PF00240)
In PDB
Mus musculus (mouse)Elongin 18 kDa subunit, Elongin-B, EloB, RNA polymerase II transcription factor SIII subunit B, SIII p18
3CTranscription elongation factor B polypeptide 1polymer9610869.51UniProt (P83940)
Pfam (PF03931)
In PDB
Mus musculus (mouse)Elongin 15 kDa subunit, Elongin-C, EloC, RNA polymerase II transcription factor SIII subunit C, SIII p15, Stromal membrane-associated protein SMAP1B homolog
4DCullin-5polymer37844010.41UniProt (Q93034)
Pfam (PF00888)
In PDB
Homo sapiens (human)CUL-5, Vasopressin-activated calcium-mobilizing receptor 1, VACM-1
Sequence modifications
A: 32 - 198 (UniProt: O14508)
PDBExternal DatabaseDetails
His 26-expression tag
Met 27-expression tag
Asp 28-expression tag
Pro 29-expression tag
Glu 30-expression tag
Phe 31-expression tag
C: 17 - 112 (UniProt: P83940)
PDBExternal DatabaseDetails
Pro 100Ala 100SEE REMARK 999
D: 10 - 386 (UniProt: Q93034)
PDBExternal DatabaseDetails
Arg 341Val 341engineered mutation
Asp 345Leu 345engineered mutation
Val 387-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight87878.5
All*Total formula weight87878.5
*Water molecules are not included.

225158

PDB entries from 2024-09-18

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