4J7B

Crystal structure of polo-like kinase 1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, D)	Polo-like kinase	polymer	297	34106.9	2	UniProt (Q6DRK7) Pfam (PF00069)	Danio rerio (leopard danio zebra danio zebra fish)	Uncharacterized protein
2	B, E (B, E)	Polo-like kinase	polymer	237	27206.2	2	UniProt (Q6DRK7) Pfam (PF00659)	Danio rerio (leopard danio zebra danio zebra fish)	Uncharacterized protein
3	C, F (C, F)	205 kDa microtubule-associated protein	polymer	58	6686.3	2	UniProt (P23226)	Drosophila melanogaster (Fruit fly)
4	G, H, I, J, K... (A, B, C, D, E...)	water	water		18.0	360	Chemie (HOH)

Sequence modifications

A, D: 18 - 312 (UniProt: Q6DRK7)

PDB	External Database	Details
Met 16	-	expression tag
Gly 17	-	expression tag
Asn 162	Asp 162	engineered mutation
Phe 192	Glu 192	engineered mutation

B, E: 360 - 595 (UniProt: Q6DRK7)

PDB	External Database	Details
Met 359	-	expression tag
Gly 384	Asp 384	engineered mutation

C, F: 276 - 325 (UniProt: P23226)

PDB	External Database	Details
Met 268	-	expression tag
Gly 269	-	expression tag
His 270	-	expression tag
His 271	-	expression tag
His 272	-	expression tag
His 273	-	expression tag
His 274	-	expression tag
His 275	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	135998.8
All*	Total formula weight	135998.8

*Water molecules are not included.