4J6G

CRYSTAL STRUCTURE OF LIGHT AND DcR3 COMPLEX

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Tumor necrosis factor ligand superfamily member 14	polymer	165	18188.5	2	UniProt (O43557) Pfam (PF00229) In PDB	Homo sapiens (human)	Herpes virus entry mediator ligand, HVEM-L, Herpesvirus entry mediator ligand, Tumor necrosis factor ligand superfamily member 14, membrane form, Tumor necrosis factor ligand superfamily member 14, soluble form
2	C, D	Tumor necrosis factor receptor superfamily member 6B	polymer	174	19044.2	2	UniProt (O95407) Pfam (PF00020) In PDB	Homo sapiens (human)	Decoy receptor 3, DcR3, Decoy receptor for Fas ligand, M68
3	E	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G81315DD)
4	A, B	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
5	C, D	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
6	D	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
7		water	water		18.0	46	Chemie (HOH)

Sequence modifications

A, B: 83 - 240 (UniProt: O43557)

PDB	External Database	Details
His 76	-	expression tag
His 77	-	expression tag
His 78	-	expression tag
His 79	-	expression tag
His 80	-	expression tag
His 81	-	expression tag
Gly 82	-	expression tag
Glu 214	Lys 214	engineered mutation

C, D: 30 - 195 (UniProt: O95407)

PDB	External Database	Details
Thr 196	-	expression tag
Gly 197	-	expression tag
His 198	-	expression tag
His 199	-	expression tag
His 200	-	expression tag
His 201	-	expression tag
His 202	-	expression tag
His 203	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	74465.5
Branched	Number of molecules	1
	Total formula weight	748.7
Non-Polymers*	Number of molecules	5
	Total formula weight	340.7
All*	Total formula weight	75554.9

*Water molecules are not included.