4J57

Structure of Plasmodium falciparum thioredoxin reductase-thioredoxin complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Thioredoxin reductase 2	polymer	541	59752.2	2	UniProt (P61076) Pfam (PF00890) Pfam (PF00070) Pfam (PF02852)	Plasmodium falciparum	TrxR2
2	C, D (E, F)	Thioredoxin	polymer	114	12854.5	2	UniProt (Q7KQL8) Pfam (PF00085)	Plasmodium falciparum	Trx
3	E, G (A, B)	FLAVIN-ADENINE DINUCLEOTIDE	non-polymer		785.5	2	Chemie (FAD)
4	F (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
5	H, I (A, B)	water	water		18.0	25	Chemie (HOH)

Sequence modifications

A, B: 1 - 541 (UniProt: P61076)

PDB	External Database	Details
Ser 540	Cys 616	engineered mutation

E, F: 2 - 104 (UniProt: Q7KQL8)

PDB	External Database	Details
Arg -9	-	expression tag
Gly -8	-	expression tag
Ser -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
Gly 0	-	expression tag
Ser 1	-	expression tag
Ser 33	Cys 33	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	145213.3
Non-Polymers*	Number of molecules	3
	Total formula weight	1663.2
All*	Total formula weight	146876.4

*Water molecules are not included.