4J57
Structure of Plasmodium falciparum thioredoxin reductase-thioredoxin complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| A | 0045454 | biological_process | cell redox homeostasis |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| B | 0045454 | biological_process | cell redox homeostasis |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0015035 | molecular_function | protein-disulfide reductase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0015035 | molecular_function | protein-disulfide reductase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE FAD A 601 |
| Chain | Residue |
| A | ILE47 |
| A | GLY86 |
| A | THR87 |
| A | CYS88 |
| A | VAL91 |
| A | GLY92 |
| A | CYS93 |
| A | LYS96 |
| A | GLY159 |
| A | ALA161 |
| A | ALA191 |
| A | GLY48 |
| A | THR192 |
| A | GLY193 |
| A | ARG316 |
| A | ASP319 |
| A | LEU323 |
| A | GLY356 |
| A | ASP357 |
| A | GLU364 |
| A | LEU365 |
| A | ALA366 |
| A | GLY50 |
| A | PRO367 |
| A | HOH701 |
| A | HOH704 |
| A | HOH711 |
| B | HIS509 |
| A | PRO51 |
| A | GLY52 |
| A | ASP71 |
| A | TYR72 |
| A | VAL73 |
| A | LYS74 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE GOL A 602 |
| Chain | Residue |
| A | LYS58 |
| site_id | AC3 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE FAD B 600 |
| Chain | Residue |
| A | HIS509 |
| B | GLY48 |
| B | GLY50 |
| B | PRO51 |
| B | GLY52 |
| B | ASP71 |
| B | TYR72 |
| B | LYS74 |
| B | GLY86 |
| B | THR87 |
| B | CYS88 |
| B | VAL91 |
| B | GLY92 |
| B | CYS93 |
| B | LYS96 |
| B | GLY159 |
| B | LEU160 |
| B | ALA161 |
| B | ALA191 |
| B | THR192 |
| B | GLY193 |
| B | TYR232 |
| B | VAL233 |
| B | ARG316 |
| B | ASP319 |
| B | GLY356 |
| B | ASP357 |
| B | GLU364 |
| B | LEU365 |
| B | ALA366 |
| B | PRO367 |
| B | HOH701 |
| B | HOH702 |
| B | HOH704 |
Functional Information from PROSITE/UniProt
| site_id | PS00076 |
| Number of Residues | 11 |
| Details | PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCVnvGCVP |
| Chain | Residue | Details |
| A | GLY85-PRO95 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Nucleophile => ECO:0000250|UniProtKB:P10599 |
| Chain | Residue | Details |
| E | CYS30 | |
| E | SER33 | |
| F | CYS30 | |
| F | SER33 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: Deprotonates C-terminal active site Cys => ECO:0000305 |
| Chain | Residue | Details |
| E | ASP24 | |
| B | THR87 | |
| B | GLY92 | |
| B | ALA161 | |
| B | ASP357 | |
| B | GLU364 | |
| F | ASP24 | |
| A | THR87 | |
| A | GLY92 | |
| A | ALA161 | |
| A | ASP357 | |
| A | GLU364 | |
| B | PRO51 | |
| B | ASP71 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | SITE: Contributes to redox potential value => ECO:0000305 |
| Chain | Residue | Details |
| E | GLY31 | |
| E | PRO32 | |
| F | GLY31 | |
| F | PRO32 |
