4J4P
The complex of human IgE-Fc with two bound Fab fragments
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Ig epsilon chain C region | polymer | 323 | 35930.3 | 2 | UniProt (P01854) Pfam (PF07654) | Homo sapiens (human) | |
| 2 | C, E (H, C) | Immunoglobulin G Fab Fragment Heavy Chain | polymer | 249 | 27190.4 | 2 | Homo sapiens | ||
| 3 | D, F (L, D) | Immunoglobulin G Fab Fragment Light Chain | polymer | 235 | 24841.5 | 2 | Homo sapiens | ||
| 4 | G, H (E, F) | beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 2 | In PDB GlyTouCan (G89225LT) | |||
| 5 | I, J, K, L, M... (A, B, H, L, C...) | water | water | 18.0 | 41 | Chemie (HOH) |
Sequence modifications
A, B: 225 - 546 (UniProt: P01854)
| PDB | External Database | Details |
|---|---|---|
| Gln 265 | Asn 146 | engineered mutation |
| Gln 371 | Asn 252 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 175924.4 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1821.6 | |
| All* | Total formula weight | 177746.1 |
