4J4L

Modular evolution and design of the protein binding interface

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Internalin B,REPEAT MODULES,Variable lymphocyte receptor B	polymer	267	30059.1	2	UniProt (A4L9V2) UniProt (Q4G1L3) Pfam (PF12354) Pfam (PF13855) Pfam (PF11921)	Listeria monocytogenes
2	C, D (C, D)	Interleukin-6	polymer	168	19196.9	2	UniProt (P05231) Pfam (PF00489)	Homo sapiens (Human)	IL-6,B-cell stimulatory factor 2,BSF-2,CTL differentiation factor,CDF,Hybridoma growth factor,Interferon beta-2,IFN-beta-2
3	E, F, G, H (A, B, C, D)	water	water		18.0	158	Chemie (HOH)

Sequence modifications

A, B: 43 - 100 (UniProt: A4L9V2)

PDB	External Database	Details
Ala 59	Asp 59	conflict

A, B: 101 - 209 (PDB: 4J4L)
A, B: 210 - 301 (UniProt: Q4G1L3)

PDB	External Database	Details
Leu 302	-	expression tag
Glu 303	-	expression tag
His 304	-	expression tag
His 305	-	expression tag
His 306	-	expression tag
His 307	-	expression tag
His 308	-	expression tag
His 309	-	expression tag

C, D: 19 - 184 (UniProt: P05231)

PDB	External Database	Details
Gly 17	-	expression tag
Ser 18	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	98512.1
All*	Total formula weight	98512.1

*Water molecules are not included.