4IXP

Crystal structure of Maternal Embryonic Leucine Zipper Kinase (MELK)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Maternal embryonic leucine zipper kinase	polymer	348	40423.8	1	UniProt (Q14680) Pfam (PF00069) Pfam (PF21594)	Homo sapiens (human)	hMELK, Protein kinase Eg3, pEg3 kinase, Protein kinase PK38, hPK38, Tyrosine-protein kinase MELK
2	B (A)	water	water		18.0	39	Chemie (HOH)

Sequence modifications

A: 1 - 340 (UniProt: Q14680)

PDB	External Database	Details
Arg 40	Lys 40	engineered mutation
Ala 150	Asp 150	engineered mutation
Leu 341	-	expression tag
Glu 342	-	expression tag
His 343	-	expression tag
His 344	-	expression tag
His 345	-	expression tag
His 346	-	expression tag
His 347	-	expression tag
His 348	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	40423.8
All*	Total formula weight	40423.8

*Water molecules are not included.