4IWO
Crystal structure and mechanism of activation of TBK1
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Serine/threonine-protein kinase TBK1 | polymer | 660 | 75922.8 | 1 | UniProt (Q9UHD2) Pfam (PF00069) Pfam (PF18396) Pfam (PF18394) In PDB | Homo sapiens (human) | NF-kappa-B-activating kinase, T2K, TANK-binding kinase 1 |
2 | A | N-{3-[(5-cyclopropyl-2-{[3-(2-oxopyrrolidin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]propyl}cyclobutanecarboxamide | non-polymer | 448.6 | 1 | Chemie (1H4) | |||
3 | water | water | 18.0 | 5 | Chemie (HOH) |
Sequence modifications
A: 2 - 657 (UniProt: Q9UHD2)
PDB | External Database | Details |
---|---|---|
Gly -2 | - | expression tag |
Ala -1 | - | expression tag |
Met 0 | - | expression tag |
Gly 1 | - | expression tag |
Ala 172 | Ser 172 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 75922.8 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 448.6 | |
All* | Total formula weight | 76371.4 |