Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4IWO

Crystal structure and mechanism of activation of TBK1

Functional Information from GO Data
ChainGOidnamespacecontents
A0002218biological_processactivation of innate immune response
A0002753biological_processcytoplasmic pattern recognition receptor signaling pathway
A0003676molecular_functionnucleic acid binding
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004676molecular_function3-phosphoinositide-dependent protein kinase activity
A0004677molecular_functionDNA-dependent protein kinase activity
A0004679molecular_functionAMP-activated protein kinase activity
A0004694molecular_functioneukaryotic translation initiation factor 2alpha kinase activity
A0004711molecular_functionribosomal protein S6 kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006338biological_processchromatin remodeling
A0006468biological_processprotein phosphorylation
A0006954biological_processinflammatory response
A0007249biological_processcanonical NF-kappaB signal transduction
A0009615biological_processresponse to virus
A0010468biological_processregulation of gene expression
A0010508biological_processpositive regulation of autophagy
A0010628biological_processpositive regulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0016236biological_processmacroautophagy
A0016239biological_processpositive regulation of macroautophagy
A0018105biological_processpeptidyl-serine phosphorylation
A0018107biological_processpeptidyl-threonine phosphorylation
A0019903molecular_functionprotein phosphatase binding
A0032479biological_processregulation of type I interferon production
A0032481biological_processpositive regulation of type I interferon production
A0032727biological_processpositive regulation of interferon-alpha production
A0032728biological_processpositive regulation of interferon-beta production
A0033138biological_processpositive regulation of peptidyl-serine phosphorylation
A0034142biological_processtoll-like receptor 4 signaling pathway
A0035175molecular_functionhistone H3S10 kinase activity
A0035402molecular_functionhistone H3T11 kinase activity
A0035403molecular_functionhistone H3T6 kinase activity
A0035979molecular_functionhistone H2AXS139 kinase activity
A0042802molecular_functionidentical protein binding
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0043231cellular_componentintracellular membrane-bounded organelle
A0044022molecular_functionhistone H3S28 kinase activity
A0044023molecular_functionhistone H4S1 kinase activity
A0044024molecular_functionhistone H2AS1 kinase activity
A0044025molecular_functionhistone H2BS14 kinase activity
A0044565biological_processdendritic cell proliferation
A0045087biological_processinnate immune response
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0050830biological_processdefense response to Gram-positive bacterium
A0051219molecular_functionphosphoprotein binding
A0051607biological_processdefense response to virus
A0060337biological_processtype I interferon-mediated signaling pathway
A0060340biological_processpositive regulation of type I interferon-mediated signaling pathway
A0061470biological_processT follicular helper cell differentiation
A0072354molecular_functionhistone H3T3 kinase activity
A0072371molecular_functionhistone H2AS121 kinase activity
A0072518molecular_functionRho-dependent protein serine/threonine kinase activity
A0106310molecular_functionprotein serine kinase activity
A0140374biological_processantiviral innate immune response
A0140823molecular_functionhistone H2BS36 kinase activity
A0140855molecular_functionhistone H3S57 kinase activity
A0140857molecular_functionhistone H3T45 kinase activity
A0140896biological_processcGAS/STING signaling pathway
A1902554cellular_componentserine/threonine protein kinase complex
A1904262biological_processnegative regulation of TORC1 signaling
A1904263biological_processpositive regulation of TORC1 signaling
A1904417biological_processpositive regulation of xenophagy
A1904515biological_processpositive regulation of TORC2 signaling
A1990244molecular_functionhistone H2AT120 kinase activity
Functional Information from PDB Data
site_idAC1
Number of Residues14
DetailsBINDING SITE FOR RESIDUE 1H4 A 701
ChainResidue
ALEU15
APRO90
AGLY92
AMET142
ATHR156
AASP157
AGLY16
AVAL23
AARG25
AVAL68
AMET86
AGLU87
APHE88
ACYS89

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGQGATANVFrGrhkktgdl..........FAIK
ChainResidueDetails
ALEU15-LYS38

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor => ECO:0000305|PubMed:23453971, ECO:0000305|PubMed:23453972, ECO:0000305|PubMed:30842653
ChainResidueDetails
AASP135

site_idSWS_FT_FI2
Number of Residues1
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
ALEU15

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING: BINDING => ECO:0000305
ChainResidueDetails
ALYS38

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine; by autocatalysis and IKKB => ECO:0000269|PubMed:11839743, ECO:0000269|PubMed:22851595, ECO:0000269|PubMed:23746807
ChainResidueDetails
AALA172

site_idSWS_FT_FI5
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23453971
ChainResidueDetails
ALYS30
ALYS401

227344

PDB entries from 2024-11-13

PDB statisticsPDBj update infoContact PDBjnumon