4ISO
Crystal Structure of Matriptase in complex with its inhibitor HAI-1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Suppressor of tumorigenicity 14 protein | polymer | 241 | 26477.8 | 1 | UniProt (Q9Y5Y6) Pfam (PF00089) In PDB | Homo sapiens (human) | Matriptase, Membrane-type serine protease 1, MT-SP1, Prostamin, Serine protease 14, Serine protease TADG-15, Tumor-associated differentially-expressed gene 15 protein |
| 2 | B | Kunitz-type protease inhibitor 1 | polymer | 60 | 6941.8 | 1 | UniProt (O43278) Pfam (PF00014) In PDB | Homo sapiens (human) | Hepatocyte growth factor activator inhibitor type 1, HAI-1 |
| 3 | A | GLUTATHIONE | non-polymer | 307.3 | 1 | Chemie (GSH) | |||
| 4 | A | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | A, B | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 4 | Chemie (PEG) | |||
| 6 | A | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 7 | water | water | 18.0 | 182 | Chemie (HOH) |
Sequence modifications
A: 16 - 244 (UniProt: Q9Y5Y6)
| PDB | External Database | Details |
|---|---|---|
| Gln 164 | Asn 772 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 33419.6 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1066.2 | |
| All* | Total formula weight | 34485.8 |
