4IS0
Structural Insights into Omega-Class Glutathione Transferases: A Snapshot of Enzyme Reduction and Identification of the Non-Catalytic Ligandin Site.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Glutathione S-transferase omega-1 | polymer | 241 | 27567.8 | 1 | UniProt (P78417) Pfam (PF13409) Pfam (PF14497) | Homo sapiens (human) | GSTO-1, Glutathione S-transferase omega 1-1, GSTO 1-1, Glutathione-dependent dehydroascorbate reductase, Monomethylarsonic acid reductase, MMA(V) reductase, S-(Phenacyl)glutathione reductase, SPG-R |
| 2 | B, C (A) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 3 | D (A) | OXIDIZED GLUTATHIONE DISULFIDE | non-polymer | 612.6 | 1 | Chemie (GDS) | |||
| 4 | E (A) | 2,3-DIHYDROXY-1,4-DITHIOBUTANE | non-polymer | 154.3 | 1 | Chemie (DTT) | |||
| 5 | F (A) | L-gamma-glutamyl-S-[2-(4-nitrophenyl)-2-oxoethyl]-L-cysteinylglycine | non-polymer | 470.5 | 1 | Chemie (1R4) | |||
| 6 | G (A) | water | water | 18.0 | 140 | Chemie (HOH) |
Sequence modifications
A: 1 - 241 (UniProt: P78417)
| PDB | External Database | Details |
|---|---|---|
| Ala 32 | Cys 32 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 27567.8 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1429.5 | |
| All* | Total formula weight | 28997.2 |
