4IS0
Structural Insights into Omega-Class Glutathione Transferases: A Snapshot of Enzyme Reduction and Identification of the Non-Catalytic Ligandin Site.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004364 | molecular_function | glutathione transferase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006749 | biological_process | glutathione metabolic process |
| A | 0010880 | biological_process | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| A | 0010881 | biological_process | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
| A | 0014810 | biological_process | positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019852 | biological_process | L-ascorbic acid metabolic process |
| A | 0042178 | biological_process | xenobiotic catabolic process |
| A | 0045174 | molecular_function | glutathione dehydrogenase (ascorbate) activity |
| A | 0050610 | molecular_function | methylarsonate reductase activity |
| A | 0051280 | biological_process | negative regulation of release of sequestered calcium ion into cytosol |
| A | 0051281 | biological_process | positive regulation of release of sequestered calcium ion into cytosol |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0071243 | biological_process | cellular response to arsenic-containing substance |
| A | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 901 |
| Chain | Residue |
| A | ARG39 |
| A | HIS49 |
| A | HOH1006 |
| A | HOH1023 |
| A | HOH1122 |
| A | HOH1128 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 902 |
| Chain | Residue |
| A | GLN79 |
| A | HOH1051 |
| A | HOH1110 |
| A | GLU21 |
| A | GLY22 |
| A | SER78 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE GDS A 903 |
| Chain | Residue |
| A | ALA32 |
| A | PRO33 |
| A | PHE34 |
| A | LEU56 |
| A | LYS57 |
| A | LYS59 |
| A | LEU71 |
| A | VAL72 |
| A | PRO73 |
| A | GLU85 |
| A | SER86 |
| A | TRP222 |
| A | TYR229 |
| A | HOH1001 |
| A | HOH1040 |
| A | HOH1073 |
| A | HOH1090 |
| A | HOH1092 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DTT A 904 |
| Chain | Residue |
| A | TYR84 |
| A | CYS112 |
| A | MET115 |
| A | ILE116 |
| A | HOH1126 |
| site_id | AC5 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE 1R4 A 905 |
| Chain | Residue |
| A | ARG37 |
| A | ALA87 |
| A | GLU91 |
| A | LYS114 |
| A | LYS114 |
| A | LEU117 |
| A | GLU118 |
| A | SER121 |
| A | SER121 |
| A | MET172 |
| A | LEU176 |
| A | HOH1025 |
| A | HOH1089 |
| A | HOH1093 |
| A | HOH1097 |
| A | HOH1134 |
| A | HOH1134 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 79 |
| Details | Domain: {"description":"GST N-terminal"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 124 |
| Details | Domain: {"description":"GST C-terminal"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"10783391","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10783391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21106529","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
