4IRZ
Crystal structure of A4b7 headpiece complexed with Fab Natalizumab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Integrin alpha4 subunit | polymer | 597 | 65644.7 | 1 | Pfam (PF01839) Pfam (PF08441) UniProt (by SIFTS) (G1TY34) | Oryctolagus cuniculus | |
| 2 | B (L) | Fab Natalizumab light chain | polymer | 210 | 23289.9 | 1 | Homo sapiens (human) | ||
| 3 | C (H) | Fab Natalizumab heavy chain | polymer | 222 | 24001.8 | 1 | Homo sapiens (human) | ||
| 4 | D (B) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 5 | E, F, G (A) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
| 6 | H, I, J, K (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 7 | L (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 8 | M (A) | ETHYL DIMETHYL AMMONIO PROPANE SULFONATE | non-polymer | 195.3 | 1 | Chemie (NDS) | |||
| 9 | N (H) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 10 | O, P (A, L) | water | water | 18.0 | 13 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 112936.4 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 586.5 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1329.5 | |
| All* | Total formula weight | 114852.4 |
