4IQR

Multi-Domain Organization of the HNF4alpha Nuclear Receptor Complex on DNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, E, F	Hepatocyte nuclear factor 4-alpha	polymer	338	38567.6	4	UniProt (P41235) Pfam (PF00105) Pfam (PF00104) In PDB	Homo sapiens (human)	HNF-4-alpha, Nuclear receptor subfamily 2 group A member 1, Transcription factor 14, TCF-14, Transcription factor HNF-4
2	C, G	DNA (5'-D(*GP*GP*AP*AP*CP*TP*AP*GP*GP*TP*CP*AP*AP*AP*GP*GP*TP*CP*AP*G)-3')	polymer	20	6232.1	2
3	D, H	DNA (5'-D(*CP*CP*TP*GP*AP*CP*CP*TP*TP*TP*GP*AP*CP*CP*TP*AP*GP*TP*TP*C)-3')	polymer	20	6035.9	2
4	I, J, K, L	Nuclear receptor coactivator 2	polymer	13	1621.9	4	UniProt (Q15596) In PDB	Homo sapiens	NCoA-2, Class E basic helix-loop-helix protein 75, bHLHe75, Transcriptional intermediary factor 2, hTIF2
5	A, B, E, F	MYRISTIC ACID	non-polymer		228.4	4	Chemie (MYR)
6	A, B, E, F	ZINC ION	non-polymer		65.4	8	Chemie (ZN)

Sequence modifications

A, B, E, F: 46 - 368 (UniProt: P41235)

PDB	External Database	Details
Met 31	-	initiating methionine
Ala 32	-	expression tag
His 33	-	expression tag
His 34	-	expression tag
His 35	-	expression tag
His 36	-	expression tag
His 37	-	expression tag
His 38	-	expression tag
Val 39	-	expression tag
Asp 40	-	expression tag
Asp 41	-	expression tag
Asp 42	-	expression tag
Asp 43	-	expression tag
Lys 44	-	expression tag
Met 45	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	185293.9
Non-Polymers*	Number of molecules	12
	Total formula weight	1436.8
All*	Total formula weight	186730.7

*Water molecules are not included.