Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4IQR

Multi-Domain Organization of the HNF4alpha Nuclear Receptor Complex on DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0003707	molecular_function	nuclear steroid receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
A	0008270	molecular_function	zinc ion binding
A	0043565	molecular_function	sequence-specific DNA binding
B	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0003707	molecular_function	nuclear steroid receptor activity
B	0005634	cellular_component	nucleus
B	0006355	biological_process	regulation of DNA-templated transcription
B	0008270	molecular_function	zinc ion binding
B	0043565	molecular_function	sequence-specific DNA binding
E	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
E	0003677	molecular_function	DNA binding
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0003707	molecular_function	nuclear steroid receptor activity
E	0005634	cellular_component	nucleus
E	0006355	biological_process	regulation of DNA-templated transcription
E	0008270	molecular_function	zinc ion binding
E	0043565	molecular_function	sequence-specific DNA binding
F	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
F	0003677	molecular_function	DNA binding
F	0003700	molecular_function	DNA-binding transcription factor activity
F	0003707	molecular_function	nuclear steroid receptor activity
F	0005634	cellular_component	nucleus
F	0006355	biological_process	regulation of DNA-templated transcription
F	0008270	molecular_function	zinc ion binding
F	0043565	molecular_function	sequence-specific DNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MYR A 401

Chain	Residue
A	SER181
A	GLN185
A	ARG226
A	LEU236
A	GLY237
A	MET252
A	GLN345

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 402

Chain	Residue
A	CYS68
A	CYS71
A	CYS51
A	CYS54

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 403

Chain	Residue
A	CYS87
A	CYS93
A	CYS103
A	CYS106

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MYR B 401

Chain	Residue
B	VAL178
B	SER181
B	GLN185
B	ARG226
B	LEU236
B	GLY237
B	MET252

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 402

Chain	Residue
B	CYS51
B	CYS54
B	CYS68
B	CYS71

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 403

Chain	Residue
B	CYS87
B	CYS93
B	CYS103
B	CYS106

site_id	AC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE MYR E 401

Chain	Residue
E	VAL178
E	SER181
E	MET182
E	GLN185
E	ARG226
E	LEU236
E	GLY237
E	MET252
E	SER256
E	ILE259

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 402

Chain	Residue
E	CYS51
E	CYS54
E	CYS68
E	CYS71

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 403

Chain	Residue
E	CYS87
E	CYS93
E	CYS103
E	CYS106

site_id	BC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE MYR F 401

Chain	Residue
F	SER181
F	GLN185
F	ALA223
F	ARG226
F	MET252
F	VAL255
F	SER256
F	ILE259
F	ILE346

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 402

Chain	Residue
F	CYS51
F	CYS54
F	CYS68
F	CYS71

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 403

Chain	Residue
F	CYS87
F	CYS93
F	CYS103
F	CYS106

Functional Information from PROSITE/UniProt

site_id	PS00031
Number of Residues	27
Details	NUCLEAR_REC_DBD_1 Nuclear hormones receptors DNA-binding region signature. CaiCg.Dratgk.HYgassCdgCkgFFrR

Chain	Residue	Details
A	CYS51-ARG77

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	300
Details	DNA_BIND: Nuclear receptor => ECO:0000255\|PROSITE-ProRule:PRU00407

Chain	Residue	Details
A	SER48-ASN123
B	SER48-ASN123
E	SER48-ASN123
F	SER48-ASN123

site_id	SWS_FT_FI2
Number of Residues	176
Details	ZN_FING: NR C4-type => ECO:0000255\|PROSITE-ProRule:PRU00407

Chain	Residue	Details
A	CYS51-CYS71
A	CYS87-CYS111
B	CYS51-CYS71
B	CYS87-CYS111
E	CYS51-CYS71
E	CYS87-CYS111
F	CYS51-CYS71
F	CYS87-CYS111

site_id	SWS_FT_FI3
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000269\|PubMed:21708125

Chain	Residue	Details
A	SER133
A	SER158
B	SER133
B	SER158
E	SER133
E	SER158
F	SER133
F	SER158

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P22449

Chain	Residue	Details
A	SER134
B	SER134
E	SER134
F	SER134

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	TYR135
B	TYR135
E	TYR135
F	TYR135

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000269\|PubMed:21708125

Chain	Residue	Details
A	THR157
B	THR157
E	THR157
F	THR157

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphoserine; by AMPK => ECO:0000269\|PubMed:12740371

Chain	Residue	Details
A	SER304
B	SER304
E	SER304
F	SER304

site_id	SWS_FT_FI8
Number of Residues	12
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:21708125

Chain	Residue	Details
A	LYS225
F	LYS225
F	LYS298
A	LYS298
B	LYS225
B	LYS298
E	LYS225
E	LYS298

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)