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4IOQ

Crystal Structure of the first bromodomain of BRD4 in complex with pyrrolidin-2-one

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Bromodomain-containing protein 4polymer12715099.41UniProt (O60885)
Pfam (PF00439)
Homo sapiens (human)Protein HUNK1
2B
(A)
pyrrolidin-2-onenon-polymer85.11Chemie (BAQ)
3C, D, E, F, G
(A)
1,2-ETHANEDIOLnon-polymer62.15Chemie (EDO)
4H
(A)
waterwater18.0153Chemie (HOH)
Sequence modifications
A: 44 - 168 (UniProt: O60885)
PDBExternal DatabaseDetails
Ser 42-expression tag
Met 43-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight15099.4
Non-Polymers*Number of molecules6
Total formula weight395.4
All*Total formula weight15494.8
*Water molecules are not included.

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PDB entries from 2025-07-16

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