4IOQ

Crystal Structure of the first bromodomain of BRD4 in complex with pyrrolidin-2-one

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE BAQ A 201

Chain	Residue
A	PRO82
A	VAL87
A	ASN140
A	HOH316
A	HOH340

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 202

Chain	Residue
A	ASN135
A	ILE100
A	ILE101
A	LYS102
A	THR103

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 203

Chain	Residue
A	TRP81
A	LYS99
A	HOH311
A	HOH329
A	HOH353
A	HOH411

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 204

Chain	Residue
A	TYR137
A	GLN159
A	LYS160

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 205

Chain	Residue
A	GLN59
A	LEU63
A	LEU114
A	ASN117
A	HOH376
A	HOH417

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 206

Chain	Residue
A	PRO47
A	PRO48
A	PRO86
A	GLY108
A	THR109
A	LYS112
A	HOH421

---

Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY

Chain	Residue	Details
A	ALA80-TYR139

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	106
Details	Domain: {"description":"Bromo 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Site: {"description":"Acetylated histone binding","evidences":[{"source":"PubMed","id":"22464331","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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