4IMO
Crystal structure of wild type human Lipocalin PGDS in complex with substrate analog U44069
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Lipocalin-type prostaglandin-D synthase | polymer | 176 | 19748.1 | 1 | UniProt (P41222) Pfam (PF00061) | Homo sapiens (human) | Beta-trace protein, Cerebrin-28, Glutathione-independent PGD synthase, Prostaglandin-H2 D-isomerase, Prostaglandin-D2 synthase, PGD2 synthase, PGDS, PGDS2 |
| 2 | B, C (A) | (5E)-7-{(1R,4S,5S,6R)-5-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2-oxabicyclo[2.2.1]hept-6-yl}hept-5-enoic acid | non-polymer | 350.5 | 2 | Chemie (PWZ) | |||
| 3 | D, E (A) | THIOCYANATE ION | non-polymer | 58.1 | 2 | Chemie (SCN) | |||
| 4 | F (A) | water | water | 18.0 | 82 | Chemie (HOH) |
Sequence modifications
A: 23 - 190 (UniProt: P41222)
| PDB | External Database | Details |
|---|---|---|
| Met 22 | - | expression tag |
| Ala 191 | - | expression tag |
| His 192 | - | expression tag |
| His 193 | - | expression tag |
| His 194 | - | expression tag |
| His 195 | - | expression tag |
| His 196 | - | expression tag |
| His 197 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 19748.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 817.1 | |
| All* | Total formula weight | 20565.3 |
