4IMO
Crystal structure of wild type human Lipocalin PGDS in complex with substrate analog U44069
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Lipocalin-type prostaglandin-D synthase | polymer | 176 | 19748.1 | 1 | UniProt (P41222) Pfam (PF00061) | Homo sapiens (human) | Beta-trace protein, Cerebrin-28, Glutathione-independent PGD synthase, Prostaglandin-H2 D-isomerase, Prostaglandin-D2 synthase, PGD2 synthase, PGDS, PGDS2 |
| 2 | B, C (A) | (5E)-7-{(1R,4S,5S,6R)-5-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2-oxabicyclo[2.2.1]hept-6-yl}hept-5-enoic acid | non-polymer | 350.5 | 2 | Chemie (PWZ) PubChem (25792131) PubChem (44364273) PubChem (114865) PubChem (24094168) PubChem (50930616) PubChem (50935463) PubChem (53763205) PubChem (53763207) PubChem (57720037) PubChem (44364274) PubChem (71771259) PubChem (59072914) PubChem (3643892) PubChem (90900377) PubChem (91414593) PubChem (5311386) PubChem (91746438) PubChem (124351306) PubChem (5883928) PubChem (9884788) PubChem (95065593) PubChem (6504736) PubChem (98043762) PubChem (98043763) PubChem (98043764) PubChem (98043765) PubChem (124351307) PubChem (133126631) PubChem (140454945) | |||
| 3 | D, E (A) | THIOCYANATE ION | non-polymer | 58.1 | 2 | Chemie (SCN) PubChem (9322) | |||
| 4 | F (A) | water | water | 18.0 | 82 | Chemie (HOH) |
Sequence modifications
A: 23 - 190 (UniProt: P41222)
| PDB | External Database | Details |
|---|---|---|
| Met 22 | - | expression tag |
| Ala 191 | - | expression tag |
| His 192 | - | expression tag |
| His 193 | - | expression tag |
| His 194 | - | expression tag |
| His 195 | - | expression tag |
| His 196 | - | expression tag |
| His 197 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 19748.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 817.1 | |
| All* | Total formula weight | 20565.3 |
