4IMO
Crystal structure of wild type human Lipocalin PGDS in complex with substrate analog U44069
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0001516 | biological_process | prostaglandin biosynthetic process |
A | 0004667 | molecular_function | prostaglandin-D synthase activity |
A | 0005501 | molecular_function | retinoid binding |
A | 0005504 | molecular_function | fatty acid binding |
A | 0005515 | molecular_function | protein binding |
A | 0005576 | cellular_component | extracellular region |
A | 0005615 | cellular_component | extracellular space |
A | 0005634 | cellular_component | nucleus |
A | 0005737 | cellular_component | cytoplasm |
A | 0005783 | cellular_component | endoplasmic reticulum |
A | 0005789 | cellular_component | endoplasmic reticulum membrane |
A | 0005791 | cellular_component | rough endoplasmic reticulum |
A | 0005794 | cellular_component | Golgi apparatus |
A | 0010467 | biological_process | gene expression |
A | 0016020 | cellular_component | membrane |
A | 0016853 | molecular_function | isomerase activity |
A | 0019371 | biological_process | cyclooxygenase pathway |
A | 0031965 | cellular_component | nuclear membrane |
A | 0036094 | molecular_function | small molecule binding |
A | 0043303 | biological_process | mast cell degranulation |
A | 0045187 | biological_process | regulation of circadian sleep/wake cycle, sleep |
A | 0048471 | cellular_component | perinuclear region of cytoplasm |
A | 0051384 | biological_process | response to glucocorticoid |
A | 0070062 | cellular_component | extracellular exosome |
A | 2000255 | biological_process | negative regulation of male germ cell proliferation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE PWZ A 201 |
Chain | Residue |
A | ARG42 |
A | PHE143 |
A | TRP54 |
A | LYS66 |
A | VAL68 |
A | THR80 |
A | TRP112 |
A | TYR116 |
A | PRO139 |
A | GLY140 |
site_id | AC2 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE PWZ A 202 |
Chain | Residue |
A | SER45 |
A | SER67 |
A | SER81 |
A | TYR107 |
A | SER109 |
A | TRP112 |
A | TYR149 |
A | SCN203 |
A | HOH317 |
A | HOH327 |
A | HOH382 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SCN A 203 |
Chain | Residue |
A | GLN36 |
A | ASP37 |
A | ARG85 |
A | PWZ202 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SCN A 204 |
Chain | Residue |
A | PRO32 |
A | TYR128 |
A | LEU159 |
A | LYS162 |
A | HOH350 |
Functional Information from PROSITE/UniProt
site_id | PS00213 |
Number of Residues | 14 |
Details | LIPOCALIN Lipocalin signature. NFQqdKFLGRWFSA |
Chain | Residue | Details |
A | ASN33-ALA46 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Nucleophile => ECO:0000269|PubMed:20667974 |
Chain | Residue | Details |
A | CYS65 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | CARBOHYD: O-linked (GalNAc...) serine => ECO:0000269|PubMed:23234360 |
Chain | Residue | Details |
A | SER29 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:8336134 |
Chain | Residue | Details |
A | ASN51 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:22171320, ECO:0000269|PubMed:8336134 |
Chain | Residue | Details |
A | ASN78 |